Doxorubicin - chitosan - hydroxyapatite composite coatings on titanium alloy for localized cancer therapy.

The doxorubicin-chitosan composite is deposited electrochemically on the Ti alloy post hydroxyapatite coated for reducing the side effects by sustaining release of drugs localized near the tumor to achieve the inhibition or apoptosis of cancer. The possibility of danger in case of exfoliation of medicine composite and HA agglomerates from the alloy surface due to the dynamic erosion of blood flow could be overcome with the additional surface modification by the electrochemical deposition way. The cathodic polarization tests coupled with electrochemical reactions were analyzed to speculate the deposition mechanism of doxorubicin, spectrophotometer (UV visible spectrometer) to measure doxorubicin loading and release, field emission scanning electron microscope (FESEM) to observe surface morphology, Fourier transform infrared (FTIR) spectroscopy for chemical bonding of composites, and X-ray diffractometry (XRD) for crystal structure.

[Using the Facebook Social Networking Website to Improve the Utilization of Weight Loss Programs by Community Obese Adults].

Background: In light of the known impacts of obesity on well-being, we regularly work to promote weight loss programs in community settings. However, we found that a gap exists between the need for weight loss and the utilization of healthy weight loss programs among BMI (body mass index) ≥ 27 kg/madults. The low utilization of healthy weight loss programs may lower the overall benefit of these programs.