Evidence for early encoding of speech in blind people.

Blind listeners rely more on their auditory skills than the sighted to adapt to unavailable visual information. However, it is still unclear whether the blind has stronger noise-related modulation compared with the sighted when speech is presented under adverse listening conditions. This study aims to address this research gap by constructing noisy conditions and syllable contrasts to obtain auditory middle-latency response (MLR) and long-latency response (LLR) in blind and sighted adults.

Experimental study on the flow structures and dynamics of turbulent Rayleigh-Bénard convection in an annular cell.

We conduct an experimental study on the flow structures and dynamics of turbulent Rayleigh-Bénard convection in an annular cell with radius ratio η≃0.5 and aspect ratio Γ≃4. The working fluid is water with a Prandtl number of Pr≃5.

The Pharmacokinetics and Pharmacodynamics of A Novel Recombinant Activated Human Factor VII, GEN-0828, in Hemophilia B Mice.

GEN-0828, a proposed clinical candidate for hemophilia and trauma hemorrhage treatment, is a novel recombinant activated human factor VII (rFVIIa). The purpose of this paper is to compare the pharmacokinetics and pharmacodynamics of GEN-0828 in hemophilia B mice with those of NovoSeven®, the only marketed rFVIIa product worldwide., GEN-0828 and NovoSeven® showed similar affinity bioactivity to recombinant tissue factor (rTF) in vitro.

Rare Recurrent EWSR1-PLAGL1 Rearranged Intracranial Tumor With Biphasic Epithelioid Differentiation: One Case Report With Literature Review.

EWSR1-rearranged tumors encompass a rare and heterogeneous group of entities with features of the central nervous system (CNS) mesenchymal and primary glial/neuronal tumors. EWSR1-PLAGL1 gene fusion is a particularly rare form of rearrangement. We presented a recurrent intracranial EWSR1-PLAGL1 rearranged tumor and reviewed the relevant literature.

miR-638 Serves as a Biomarker of 5-Fluorouracil Sensitivity to Neoadjuvant Chemotherapy in Breast Cancer.

Purpose: Neoadjuvant chemotherapy (NAC) is widely used to treat breast cancer (BC). The prediction and evaluation of chemotherapy responses remains a significant challenge.

Methods: MicroRNAs (miRNAs) play a crucial role in cancer drug resistance.

Light therapy: a new option for neurodegenerative diseases.

Given the increasing incidence of neurodegenerative disease (ND), recent research efforts have intensified the search for curative treatments. Despite significant research, however, existing therapeutic options for ND can only slow down the progression of the disease, but not provide a cure. Light therapy (LT) has been used to treat some mental and sleep disorders.

Statistics of velocity and temperature fluctuations in two-dimensional Rayleigh-Bénard convection.

We investigate fluctuations of the velocity and temperature fields in two-dimensional (2D) Rayleigh-Bénard (RB) convection by means of direct numerical simulations (DNS) over the Rayleigh number range 10^{6}≤Ra≤10^{10} and for a fixed Prandtl number Pr=5.3 and aspect ratio Γ=1. Our results show that there exists a counter-gradient turbulent transport of energy from fluctuations to the mean flow both locally and globally, implying that the Reynolds stress is one of the driving mechanisms of the large-scale circulation in 2D turbulent RB convection besides the buoyancy of thermal plumes.

Intracellular DNA sensing pathway of cGAS-cGAMP is decreased in human newborns and young children.

Newborns are highly susceptible to DNA virus infections, which may result from the characteristics of neonatal innate immune systems. Here we analyzed for the first time the development of innate immune sensing and signaling of intracellular DNA virus infection in human newborns and young children. Both mRNA and protein expression of cGAS, an intracellular DNA sensor, were shown to be significantly reduced in neonatal peripheral blood mononuclear cells (PBMCs).

Local dissipation scales in two-dimensional Rayleigh-Taylor turbulence.

We examine the distribution of the local dissipation scale η, Q(η), and its temporal evolution in two-dimensional (2D) Rayleigh-Taylor (RT) turbulence using direct numerical simulations at small Atwood number and unit Prandtl number. Within the self-similarity regime of the mixing zone evolution, distributions of η at small scales are found to be insensitive to the large-scale anisotropy of the system and independent of position and of the temporal evolution of the mixing zone. Our results further reveal that the present measured Q(η) agrees with those previously observed in homogeneous isotropic turbulence and in turbulent pipe flows, at least for the smallest scales around the classical Kolmogorov dissipation scale.

Single-trial analysis of cortical oscillatory activities during voluntary movements using empirical mode decomposition (EMD)-based spatiotemporal approach.

This study presents a method based on empirical mode decomposition (EMD) and a spatial template-based matching approach to extract sensorimotor oscillatory activities from multi-channel magnetoencephalographic (MEG) measurements during right index finger lifting. The longitudinal gradiometer of the sensor unit which presents most prominent SEF was selected on which each single-trial recording was decomposed into a set of intrinsic mode functions (IMFs). The correlation between each IMF of the selected channel and raw data on other channels were created and represented as a spatial map.