Publications by authors named "Yu-Long Li"

We investigated food composition and feeding selectivity of jellyfish () from the coastal aquaculture ponds in Liaodong Bay by DNA metabarcoding technology. The DNA from environmental water samples and stomach contents of were extracted and sequenced by high-throughput sequencing with 18S rDNA V4 region and mitochondrial cytochrome c oxidase subunit I (COI) as metabarcoding markers. Based on 18S rDNA metabarcoding, we detected 27 phyla in the stomach contents of , in which Mollusc was the dominant phylum followed by Arthropod, and 34 phyla in the environmental water samples, in which Pyrrophyta was the dominant phylum followed by Ciliophora and Ascomycota.

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Type 2 diabetes mellitus (T2DM) is one of the most significant health issues worldwide, with associated healthcare costs estimated to surpass USD 1054 billion by 2045. The leading cause of death in T2DM patients is the development of cardiovascular disease (CVD). In the early stages of T2DM, patients develop cardiovascular autonomic dysfunction due to the withdrawal of cardiac parasympathetic activity.

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  • The short-snout icefish is an economically significant species in China, and understanding its sex determination is vital for conservation and aquaculture efforts.
  • Research identified a specific region on chromosome 2 that plays a crucial role in determining sex, revealing significant genetic differences between males and females.
  • A new rapid genetic method based on PCR allows for the identification of the fish's sex at any developmental stage, aiding in both research and practical applications in breeding.
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  • Ochratoxin A (OTA) is harmful to human health and can lead to kidney damage, cancer, and weakened immunity.* -
  • A new dual-mode aptasensor was developed for detecting OTA, using a special metal-organic framework that enhances sensitivity through color and electrical signals.* -
  • The sensor is highly effective, detecting OTA in concentrations from 1 fg/mL to 250 ng/mL, and successfully identified OTA in various food samples like corn, wheat, and red wine.*
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The emergence of multidrug resistance (MDR) in malignant tumors is one of the major threats encountered currently by many chemotherapeutic agents. Among the various mechanisms involved in drug resistance, P-glycoprotein (P-gp, ABCB1), a member of the ABC transporter family that significantly increases the efflux of various anticancer drugs from tumor cells, and the metabolic enzyme CYP1B1 are widely considered to be two critical targets for overcoming MDR. Unfortunately, no MDR modulator has been approved by the FDA to date.

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Aims: Renal denervation (RDN) is widely investigated in multiple studies of sympathetically driven cardiovascular diseases. While the therapeutic potential of RDN for ventricular arrhythmia has been reported, the mechanisms responsible for its antiarrhythmic effect are poorly understood. Our recent study showed that macrophage expansion-induced neuroinflammation in the stellate ganglion (SG) was a critical factor for cardiac sympathetic overactivation and ventricular arrhythmogenesis in chronic heart failure (CHF).

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  • Littorinid snails, living in tough intertidal zones, serve as great models for studying genetic adaptations and karyotype evolution from their common ancestor with bilaterians.
  • Researchers created high-quality genome assemblies for two types of littorinid snails, revealing many genes linked to their survival in fluctuating environments, including those related to immune response and stress management.
  • The study found that the karyotype of littorinid snails has remained largely unchanged from the common ancestor they share with other mollusks, preserving important genetic linkages for over 500 million years, making them crucial for understanding early evolution.
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  • The Japanese eel, an important species for conservation, is known for its long migrations, but little is understood about its genetics related to this behavior.
  • Researchers created a detailed genome assembly and sequenced 218 individuals, discovering that certain genes related to exercise and navigation show strong signs of selection for long-distance migration.
  • They found low genetic diversity likely due to past population declines and identified a single panmictic population, with candidate genes linked to development and circadian rhythms, which can aid in conservation strategies.
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  • The epitranscriptomic mark -methyladenosine (mA) is a key mRNA modification in eukaryotes, particularly in plants, influencing their growth and response to the environment.
  • The discovery of the demethylase protein FTO shows that mA modification is reversible, and research tools have advanced to study this in plants, revealing its widespread presence and specific sequences.
  • The review discusses mA detection techniques, its distribution in plants, the roles of associated proteins (methyltransferases, demethylases, and readers), and how mA affects plant development and environmental interactions.
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Photothermal immunotherapy has shown great promise in the treatment of tumor metastasis. However, the thermal resistance of tumor cells substantially compromises the treatment effect of photothermal immunotherapy. Herein, a high-performance organic pyroelectric nanoplatform, Bu-TPAD-BF nanoparticles (NPs), is rationally engineered for the effective pyroelectroimmunotherapy of tumor metastasis.

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The construction of efficient methods for highly sensitive and rapid detection of disease markers is essential for the early diagnosis of serious diseases. In this paper, taking advantage of the UiO-66-NH signal molecule in combination with a waste-free entropy-driven DNA machine, a novel homogeneous electrochemical ratiometric platform is developed to detect MircoRNA (miRNA). Metal-organic framework materials (UiO-66-NH MOF) and ferrocene were utilized as electrochemical signal tags and reference probes, respectively.

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Direct conversion of hydrocarbons into amines represents an important and atom-economic goal in chemistry for decades. However, intermolecular cross-coupling of terminal alkenes with amines to form branched amines remains extremely challenging. Here, a visible-light and Co-dual catalyzed direct allylic C─H amination of alkenes with free amines to afford branched amines has been developed.

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  • The study focuses on the genetic patterns of a declining seagrass species in the Northwestern Pacific, and its introduction along North America's Pacific coast, to guide conservation efforts.
  • Researchers analyzed over 1,000 individuals from 34 populations using genetic markers to explore the phylogeography and population structure.
  • Findings revealed significant genetic divergence between northern and southern native populations, with nonnative populations tracing their origin to Japan, which may aid in predicting future expansions of the species.
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Objective: To explore clinical effect of different intervertebral fusion devices (cage) in treating postoperative recurrent lumbar disc herniation (LDH).

Methods: One hundred and forty-two LDH patients with recurrence after simple intervertebral disc nucleus pulpoideectomy from January 2019 to January 2021 were retrospectively analyzed. All patients were treated with combined underchannel fixation and interbody fusion and divided into a single anatomical group,two-anatomical group and a single banana group according to types and numbers of implanted cage.

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Introduction: This study was designed to measure the concentration and activity of urinary proteases that activate renal epithelial sodium channel (ENaC) mediated Na transport in infants with congenital heart disease, a potential mechanism for fluid retention.

Methods: Urine samples from infants undergoing cardiac surgery were collected at three time points: T1) pre-operatively, T2) 6-8 h after surgery, and T3) 24 h after diuretics. Urine was collected from five heathy infant controls.

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The development of efficient fluorescent probes and adsorbents for detecting and removing Cu, which pose potential environmental and health risks, is a highly active area of research. However, achieving simultaneously improved fluorescence detection efficiency and enhanced adsorption capacity in a single porous probe remains a significant challenge. In this study, we successfully synthesized a two-dimensional imine-based TAP-COF using 2,4,6-triformylphloroglucinol and tri(4-aminophenyl)amine as raw materials.

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Perillaldehyde is a monoterpene compound mainly from the medicinal plant Perilla frutescens (L.) Britt., which has hypolipidemic, antioxidant, antibacterial and anti-inflammatory functions.

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Oxidative stress is a deteriorating condition that arises due to an imbalance between the reactive oxygen species and the antioxidant system or defense of the body. The key reasons for the development of such conditions are malfunctioning of various cell organelles, such as mitochondria, endoplasmic reticulum, and Golgi complex, as well as physical and mental disturbances. The nervous system has a relatively high utilization of oxygen, thus making it particularly vulnerable to oxidative stress, which eventually leads to neuronal atrophy and death.

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Six-membered N-containing heterocycles, such as 2-piperidinone derivatives, with diverse substitution patterns are widespread in natural products, drug molecules and serve as key precursors for piperidines. Thus, the development of stereoselective synthesis of multi-substituted 2-piperidinones are attractive. However, existing methods heavily rely on modification of pre-synthesized backbones which require tedious multi-step procedure and suffer from limited substitution patterns.

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Imidazolinones were obtained in good yields by intramolecular hydroamination of -alkoxy ureas in the presence of an organic photocatalyst and an inorganic base. In this reaction, the -alkoxy urea anion generated by deprotonation undergoes photocatalyzed single-electron-transfer oxidation to generate the corresponding radical, which cyclizes to afford the imidazolinone ring. This new protocol grants access to an array of complex molecules containing a privileged imidazolinone core.

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Responding to tissue injury, skeletal muscles undergo the tissue destruction and reconstruction accompanied with inflammation. The immune system recognizes the molecules released from or exposed on the damaged tissue. In the local minor tissue damage, tissue-resident macrophages sequester pro-inflammatory debris to prevent initiation of inflammation.

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Heart failure (HF) is a major public health problem worldwide, especially coronary heart disease (myocardial infarction)-induced HF with reduced ejection fraction (HFrEF), which accounts for over 50% of all HF cases. An estimated 6 million American adults have HF. As a major feature of HF, cardiac sympathetic overactivation triggers arrhythmias and sudden cardiac death, which accounts for nearly 50-60% of mortality in HF patients.

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  • * After 6 weeks of reduced blood flow, BALB/c mice showed severe muscle damage, including smaller muscle fibers and increased fat and scar tissue, compared to C57BL/6 mice, which had healthier muscle characteristics.
  • * BALB/c mice also experienced greater damage to neuromuscular junctions and reduced muscle contractions, indicating they may be a suitable model for researching new treatments for PAD, though the exact reasons for the strain differences need further investigation.
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Electrochemical nanotags with strong signal input are necessary for a ratiometric electrochemical sensor to overcome the drawbacks of inaccurate detection results. In this paper, the metal-organic framework (MOF) UiO-66 was utilized as an electrochemical signal tag. A stable and strong current response at +0.

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