Protective effect of heat-processed on high fat diet-induced glucose metabolic disorders mice.

Glucose metabolic disorders (GMD) can promote insulin resistance (IR) and diabetes, and damage liver and kidney. is commonly used in the clinical treatment of diabetes, but the research on its main active constituents and GMD has not been reported yet. This study explores the therapeutic potential of gypenosides of heat-processed (HGyp) on high-fat diet-induced GMD in mice.

Saponins derived from Gynostemma pentaphyllum regulate triglyceride and cholesterol metabolism and the mechanisms: A review.

Ethnopharmacological Relevance: Gynostemma pentaphyllum (Thunb.) Makino (G. pentaphyllum) can be used for both medicinal and tea and has lipid-lowering properties.

The Content and Principle of the Rare Ginsenosides Produced from after Heat Treatment.

Ginsenoside Rg3, Rk1, and Rg5, rare ginsenosides from , have many pharmacological effects, which have attracted extensive attention. They can be obtained through the heat treatment of . In this study, scanning electron microscopy (SEM) and thermal gravity-differential thermal gravity (TG-DTG) were employed to investigate this process and the content change in ginsenosides was analyzed using liquid chromatography-mass spectrometry (LC-MS).

Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high morbidity and mortality. Targeting abnormal cholesterol metabolism is a potential therapeutic direction. Therefore, more natural drugs targeting cholesterol in HCC need to be developed.

Uncovering the anti-NSCLC effects and mechanisms of gypenosides by metabolomics and network pharmacology analysis.

Ethnopharmacological Relevance: Lung cancer is the chief reason of cancer death worldwide, and non-small cell lung cancer (NSCLC) make up the majority of lung cancers. Gypenosides are the main active constituents from Gynostemma pentaphyllum. Previous studies showed that they were used to remedy many cancers.

Dammarane-type saponins from and their cytotoxicities.

Heat-processed has shown strong activity against human lung carcinoma A549 cells. In this study, two dammarane-type saponins together with two known compounds were isolated from the ethanol extract of the heat-processed leaves of . They were identified as 2,3,12-trihydroxydammar-20(22),24-diene-3---D-glucopyranoside (, namely damulin E), 2,3,12-trihydroxydammar-20,24-diene-3---D-glucopyranoside (, namely damulin F), damulin A () and damulin B (), respectively, using NMR and mass spectra.

Alkylation of isobutane and isobutene catalyzed by trifluoromethanesulfonic acid-taurine deep eutectic solvents in polyethylene glycol.

Conventional acidic catalysts for isobutane and isobutene alkylation exhibit low alkylate selectivity. Herein, we employed an acidic deep eutectic solvent, consisting of trifluoromethanesulfonic acid and taurine, in polyethylene glycol as the catalyst. Its high conversion rate and selectivity, as well as recyclability, make it suitable for alkylate gasoline preparation.

Innovative method for the enrichment of high-polarity bioactive molecules present at low concentrations in complex matrices.

Ginsenoside Rg1 is a valuable bioactive molecule but its high polarity and low concentration in complex mixtures makes it a challenge to separate Ginsenoside Rg1 from other saponins with similar structures, resulting in low extraction efficiency. The successful development of effective Rg1 molecularly imprinted polymers that exhibit high selectivity and adsorption may offer an improved method for the enrichment of active compounds. In this work, molecularly imprinted polymers were prepared with two different methods, precipitation polymerization or surface imprinted polymerization.

[Study on preparation of phenols gastric floating tablet].

Objective: To study the preparation of phenols gastric floating tablet.

Method: The tablets which were prepared using Eudragit IV, HPMC(K4M), MCC101 and Octadecanol as excipients were evaluated by vitro floatation and releasing performance. The pressure of preparationg was also study to select the optimal preparation.