Publications by authors named "Yu-Ling Chung"
Article Synopsis
- - Prenatal exposure to traffic-related diesel exhaust particles (DEPs) was found to significantly inhibit lung development in fetal mice by reducing lung branching morphogenesis and affecting crucial growth factors.
- - RNA sequencing revealed that DEP exposure heightened inflammatory responses and decreased expression of important lung development genes, including Yes-associated protein (YAP) and fibroblast growth factor receptor 2 (FGFR2).
- - The study suggests that DEPs disrupt the Hippo signaling pathway, leading to restricted lung growth and early cellular aging during a critical stage of lung development, indicating that prenatal air pollution poses serious risks to child lung health.
Cinnamaldehyde has been demonstrated to stimulate glutathione production and the expression of phase II detoxifying enzymes in HepG2 cells. The mechanism underlying this cinnamaldehyde-mediated gene expression relies on Nrf2 transcriptional activity. Therefore, the molecular signaling events in cinnamaldehyde-mediated detoxifying enzyme expression were further investigated in this study.
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