Publications by authors named "Yu-Lin Ko"

: Despite the widespread use of lipid-lowering agents, the risk of atherosclerotic cardiovascular disease (ASCVD) remains; this residual risk has been attributed to remnant cholesterol (RC) levels. However, the causal associations between RC levels and various atherosclerosis-related cardiometabolic and vascular risk factors for ASCVD remain unclear. : Using genetic and biochemical data of 108,876 Taiwan Biobank study participants, follow-up data of 31,790 participants, and follow-up imaging data of 18,614 participants, we conducted a genome-wide association study, a Functional Mapping and Annotation analysis, and bidirectional Mendelian randomization analyses to identify the genetic determinants of RC levels and the causal associations between RC levels and various cardiometabolic and vascular risk factors.

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Human resistin is a proinflammatory cytokine involving the development and progression of cancer and cardiovascular diseases. However, prediction of long-term outcome using circulating resistin level and its genetic determinants in a population-based study remain to be explored. After genome-wide association study (GWAS), DNA methylation (DNAm) analysis and functional assays of a RETN rs370006313 variant, we tested whether resistin level and its genetic determinants can be used to determine the long-term outcomes of 5678 Taiwan Biobank (TWB) participants.

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YKL-40 is significantly associated with the prevalence and severity of coronary artery disease (CAD). YKL-40 levels are significantly associated with variations in the CHI3L1 and TRIB1 genes. We investigated candidate genes for YKL-40 levels and evaluated the prognostic value of this biomarker and corresponding variants for long-term outcomes in patients with CAD.

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Sodium taurocholate co-transporting polypeptide (NTCP), a bile acid transporter, plays a crucial role in regulating bile acid levels and influencing the risk of HBV infection. Genetic variations in the SLC10A1 gene, which encodes NTCP, affect these functions. However, the impact of SLC10A1 gene variants on the metabolic and biochemical traits remained unclear.

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Previous investigations have suggested an association between the common polymorphism E670G and Lipoprotein(a) (Lp(a)) levels, as well as a link between plasma PCSK9 levels and Lp(a) concentrations. However, the causal relationship between plasma PCSK9 and Lp(a) levels remains uncertain. In this study, we explored the association between E670G polymorphism and Lp(a) levels in 614 healthy Taiwanese individuals.

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Our study aimed to investigate if genetic variants around 16p13.3's locus, associated with erythrocyte indices and HbA1c levels, predict α-thalassemia-related erythrocyte indices, cardiometabolic traits, and diabetes risk in Taiwanese individuals. We analyzed Taiwan Biobank data, including whole-genome sequencing from 1,493 participants and genotyping arrays from 129,542 individuals.

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ABCG5 and ABCG8 are two key adenosine triphosphate-binding cassette (ABC) proteins that regulate whole-body sterol trafficking. This study aimed to elucidate the association between gene region variants and lipid profile, cardiometabolic traits, and gallstone disease history in Taiwan. A total of 1494 Taiwan Biobank participants with whole-genome sequencing data and 117,679 participants with Axiom Genome-Wide CHB Array data were enrolled for analysis.

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Background: A recent meta-analysis reported late excess mortality in patients treated with paclitaxel-coated devices (PCDs) for symptomatic femoropopliteal disease. However, this finding is controversial.

Objectives: To investigate the impact on mortality and predictors of repeat exposure to PCDs in patients with lower extremity peripheral arterial disease (LE-PAD).

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Objectives: Circulating serum amyloid A (SAA) levels are strongly associated with atherosclerotic cardiovascular disease risk and severity. The association between genetic variants, SAA levels, inflammatory marker levels, and coronary artery disease (CAD) prognosis has not been fully understood.

Materials And Methods: In total, 2199 Taiwan Biobank (TWB) participants were enrolled for a genome-wide association study (GWAS), and the long-term outcomes in 481 patients with CAD were analyzed.

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Apolipoprotein B (ApoB) plays a crucial role in lipid and lipoprotein metabolism. The effects of locus variants on lipid profiles, metabolic syndrome, and the risk of diabetes mellitus (DM) in Asian populations are unclear. We included 1478 Taiwan Biobank participants with whole-genome sequence (WGS) data and 115,088 TWB participants with Axiom genome-wide CHB array data and subjected them to genotype-phenotype analyses using locus variants.

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PCSK9 is a candidate locus for low-density lipoprotein cholesterol (LDL-C) levels. The cause-effect relationship between LDL-C levels and diabetes mellitus (DM) has been suggested to be mechanism-specific. To identify the role of and genome-wide association study (GWAS)-significant variants in LDL-C levels and the risk of DM by using Mendelian randomization (MR) analysis, a total of 75,441 Taiwan Biobank (TWB) participants was enrolled for a GWAS to determine common and rare variants and their associations with LDL-C levels.

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Article Synopsis
  • * Key findings identified specific single-nucleotide variations (SNVs) associated with cholesterol and triglyceride levels, including variants in APOE and CLPTM1, which were significantly correlated with metabolic syndrome and serum albumin levels.
  • * The results suggest that variants at the APOE locus, particularly those in APOE and APOC1, play an important role in predicting cardiometabolic traits, highlighting CLPTM1 as a new candidate gene for cholesterol regulation.
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Gout is the most common form of inflammatory arthritis in adults. Elevation serum uric acid (SUA) concentration is known to be the key to gout pathogenesis. Since the first genome-wide association study (GWAS) for SUA was performed in 2007, the number of gene loci known to be associated with hyperuricemia and gout has grown rapidly.

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Resistin and soluble suppression of tumorigenicity 2 (sST2) are useful predictors in patients with coronary artery disease (CAD). Their serum levels are significantly attributed to variations in and loci. We investigated candidate variants in the for resistin levels and those in the locus for sST2 levels and evaluated the prognostication of these two biomarkers and the corresponding variants for long-term outcomes in the patients with CAD.

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The gene is a key metabolic transcriptional transregulator with monoallelic maternal expression. variants are only associated with adipose tissue gene expression, and promoter methylation is strongly associated with age. This study investigated whether age, sex, and obesity mediate the effects of variants and DNA methylation status on body shape indices and metabolic traits.

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Background: The common non-synonymous mutation of the glucokinase regulator () gene, namely rs1260326, is widely reported to have pleiotropic effects on cardio-metabolic traits and hematological parameters.

Objective: This study aimed to identify whether other variants may have pleiotropic effects independent of the rs1260326 genotypes.

Methods: In total, 81,097 Taiwan Biobank participants were enrolled for the regional plot association studies and candidate variant analysis of the region around the gene.

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Over the past decades, the treatment of ST-segment elevation myocardial infarction (STEMI) has been redefined with the incorporation of evidence from multiple clinical trials. Recommendations from guidelines are updated regularly to reduce morbidity and mortality. However, heterogeneous care systems, physician perspectives, and patient behavior still lead to a disparity between evidence and clinical practice.

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Article Synopsis
  • The study investigates genetic factors that influence levels of soluble E-selectin (sE-selectin), which are linked to inflammation and cardiometabolic disorders, using data from the Taiwan Biobank.
  • Researchers identified several gene variants, including ABO, SELE, and FUT6, that significantly impact sE-selectin levels and found additional associations with other gene loci and various health indicators like age and BMI.
  • The findings enhance the understanding of how genetic determinants regulate sE-selectin levels, potentially offering insights into their role in inflammatory and cardiometabolic conditions.
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  • The text discusses the role of T-cadherin in adiponectin signaling, highlighting its importance in vasculature and heart muscle cells, and how it relates to adiponectin levels.
  • It explains mediation analysis as a statistical technique used to determine if a third variable (mediator) affects the relationship between two other variables, particularly focusing on the suppressive effects that may arise with adiponectin in relation to HDL-C levels.
  • The study used data from 2349 participants to investigate the link between adiponectin and HDL-C, finding that the SNP rs4783244 is associated with lower adiponectin levels which, when included in the analysis, increased the relationship between HDL-C and genetic variants, demonstrating the
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is a transmembrane mucin involved in carcinogenesis and cell signaling. Functional variants are associated with multiple metabolic and biochemical traits. This study investigated the association of functional variants with DNA methylation and various metabolic, biochemical, and hematological parameters.

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Background: Patients with coronary heart disease (CHD) who quit smoking exhibit lower rates of heart attack recurrence and mortality than their peers who continue smoking. However, most male patients with CHD resume smoking after hospital discharge.

Purpose: To explore the effectiveness of motivational interventions and mobile social network support on smoking cessation and other predictors of smoking cessation in male patients with CHD.

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Background: The corrected QT interval (QTc) predicts prognosis for the general population and patients with coronary artery disease (CAD). Growth differentiation factor-15 (GDF-15) is a biomarker of myocardial fibrosis and left ventricular (LV) remodelling. The interaction between these two parameters is unknown.

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Objective: This study aims to analyse the association of chemerin levels with several metabolic, biochemical and haematological parameters in a large Taiwanese population with relative healthy status.

Design: Cross-sectional study.

Methods: Data of 4101 healthy participants without history of hypertension, diabetes, dyslipidaemia and renal insufficiency from Taiwan Biobank were analysed.

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Background And Aims: Platelet count (PLT) is a predictor of metabolic and inflammation-related disorders. Platelets can release prochemerin, which acts as a link between coagulation and inflammation and between innate and adaptive immunity. The causal effect between PLT and circulating chemerin level has not been elucidated.

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