Publications by authors named "Yu-Lin Bao"
Background: Mitochondrial dysfunction is linked to myocardial ischemia-reperfusion (I/R) injury. Checkpoint kinase 1 (CHK1) could facilitate cardiomyocyte proliferation, however, its role on mitochondrial function in I/R injury remains unknown.
Methods: To investigate the role of CHK1 on mitochondrial function following I/R injury, cardiomyocyte-specific knockout/overexpression mouse models were generated.
Article Synopsis
- Circular RNAs (circRNAs), particularly circIGF1R, are identified as crucial for cardiac regeneration and show potential as biomarkers and therapeutic targets in heart disease.
- circIGF1R expression is higher in neonatal hearts but decreases with maturation; it is up-regulated after cardiac injury and linked to improved outcomes in patients with acute myocardial infarction.
- Mechanistically, circIGF1R promotes heart cell proliferation and reduces heart damage by interacting with DDX5, triggering the β-catenin signaling pathway, which enhances levels of growth-related proteins cyclin D1 and c-Myc.
Article Synopsis
- The peroxisome is an organelle that plays a key role in various metabolic functions, and PEX3 is a crucial regulator of these processes.
- Researchers found that knocking out PEX3 specifically in heart cells (Pex3-KO) leads to an imbalance in redox homeostasis and disrupts heart cell growth and development.
- The study suggests that PEX3 aids in heart repair by affecting plasmalogen metabolism and influencing the AKT/GSK3β signaling pathway, indicating it could be an innovative target for therapies aimed at repairing heart damage.
Article Synopsis
- CHK1-targeted cancer therapies can increase the risk of heart problems, especially when combined with gemcitabine, but the exact reasons for this are not well understood.
- The study used human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and mouse models to investigate the cardiotoxic effects caused by these treatments, finding that they led to mitochondrial damage and heart dysfunction.
- The research highlighted the importance of mitochondrial CHK1, which helps maintain mitochondrial function, and suggested that boosting levels of SIRT3 could be a promising strategy to protect against heart damage related to these cancer therapies.
Evaluating the Utility of Colchicine in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.
J Cardiovasc Pharmacol
November 2022
Colchicine has demonstrated promising effects in inhibiting local and systemic inflammation during acute coronary syndrome (ACS). However, the efficacy of colchicine in ACS is controversial. We performed a meta-analysis to assess the utility of colchicine in ACS by systematically searching randomized controlled trials.
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