Publications by authors named "Yu-Kwan Chan"
The mechanical environment is known to influence fracture healing. We speculated that connexin43 (Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load, may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols (2%, 10%, and 30% strain) on osteotomy healing.
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- - The study aimed to assess whether endothelial progenitor cell capturing stents (ECS) are at least as effective as drug-eluting stents (DES) in preventing target lesion failure (TLF) within one year after use in patients at high risk of restenosis.
- - Researchers planned to enroll 1,300 patients but had to stop the trial early when they observed a significantly higher rate of TLF (17.4%) in patients with ECS compared to those with DES (7.0%).
- - The findings indicate that ECS may not be as effective as DES for preventing restenosis in high-risk patients, suggesting further long-term studies are needed to evaluate the full potential and benefits of ECS.