Publications by authors named "Yu-Kun Yin"
Objective: To explore the potential mechanism of Yishen Qutong Granules (YSQTG) for the treatment of esophageal cancer using network pharmacology and experimental research.
Methods: The effective components and molecular mechanism of YSQTG in treating esophageal cancer were expounded based on network pharmacology and molecular docking. The key compound was identified by high-performance liquid chromatography and mass spectrometry (HPLC-MS) to verify the malignant phenotype of the key compounds in the treatment of esophageal cancer.
Article Synopsis
- The study aimed to see if using low-frequency ultrasound to help deliver a Chinese medicine formula would boost the effectiveness of interleukin-2 (IL-2) for treating malignant pleural effusion (MPE).
- 110 participants were randomly assigned to either the control group (getting IL-2) or the experimental group (getting both IL-2 and the ultrasound-enhanced Chinese medicine gel).
- Results showed the experimental group had a better remission rate and improved quality of life, indicating that the ultrasound-facilitated delivery of the Chinese medicine was beneficial in managing MPE.
Objective: To evaluate the efficacy and safety of topical delivery of modified Da-Cheng- Qi Decoction (, MDCQD) by low-frequency ultrasound sonophoresis (LFUS) in patients with refractory metastatic malignant bowel obstruction (MBO) using an objective performance criteria (OPC) design.
Methods: Fifty patients with refractory metastatic MBO were enrolled in this open-label single-arm clinical trial. Alongside fasting, gastrointestinal decompression, glycerol enema, intravenous nutrition and antisecretory therapy, a 50 g dose of MDCQD (prepared as a hydrogel) was applied through topical delivery at the site of abodminal pain or Tianshu (S 25) using LFUS for 30 min, twice daily for 5 consecutive days.