Publications by authors named "Yu-Kun Pu"
Article Synopsis
- The NLRP3 inflammasome plays a critical role in innate immunity and is linked to liver damage, with isolicoflavonol (ILF) from Macaranga indica identified as a potential inhibitor, although its mechanisms were not fully understood.
- Research methods involved fluorescent imaging and Western blot assays to assess ILF's impact on pyroptosis and NLRP3 activation in macrophages, along with the investigation of the Nrf2 signaling pathway, using an inhibitor called ML385 for validation.
- Results showed that ILF effectively reduced macrophage LDH release and IL-1β secretion in a dose-dependent manner, inhibited pyroptosis, and enhanced Nrf2 signaling, indicating its potential as a protective
Background: NIMA (never in mitosis, gene A) serine/threonine kinase 7 (NEK7) is a regulator of mitosis spindle in mammals and is considered as a drug target of inflammasome related inflammatory diseases. However, most commercially available or reported recombinant NEK7 proteins are either inactive or have low purity. These shortcomings limit the pharmacological studies and development of NEK7 inhibitors.
View Article and Find Full Text PDFEthnopharmacological Relevance: Duan Teng Yimu decoction is a Chinese herbal medicine compound with proven therapeutic effects on inflammasome-related diseases, such as rheumatoid arthritis. This decoction consists of three Chinese herbal medicines, including Leonurus japonicus (L. japonicus), which promotes the blood circulation and exhibits detumescence activity, traditionally curing gynecologic and inflammasome diseases.
View Article and Find Full Text PDFArticle Synopsis
- Four new diterpenoids, named rubellawus A-D, were discovered in the flowers of the plant Callicarpa rubella, along with three previously known compounds.
- The chemical structures of these compounds were determined using different spectroscopic techniques.
- The compounds were tested for anti-inflammatory properties, and two specific acids showed notable inhibitory effects on the NLRP3 inflammasome, making them potential candidates for further research.