Publications by authors named "Yu-Kie Chem"
Article Synopsis
- Dengue remains a significant public health issue in Malaysia, with over 600,000 cases and 1,200 deaths recorded from 2015 to 2021, marking a 100% increase from the previous seven years.
- Recent studies on the molecular epidemiology of dengue in the country are scarce, prompting this analysis of 4,004 complete envelope gene sequences from all four dengue virus serotypes collected during the same period.
- The research found that the dengue virus populations in Malaysia are highly diverse, with ongoing turnover of genotypes, and indicated that Selangor and Johor are key areas for the emergence and spread of dengue, linked to extensive networks throughout South and East Asia.
Background: More than a year after its first appearance in December 2019, the COVID-19 pandemic is still on a rampage in many parts of the world. Although several vaccines have been approved for emergency use, the emergence and rapid spread of new SARS-CoV-2 variants have sparked fears of vaccine failure due to immune evasion. Massive viral genome sequencing has been recommended to track the genetic changes that could lead to adverse consequences.
View Article and Find Full Text PDFCharacterization of 14,079 circulating dengue viruses in a cross-border surveillance program, UNITEDengue, revealed that the 2013 outbreaks in Singapore and Malaysia were associated with replacement of predominant serotype. While the predominant virus in Singapore switched from DENV2 to DENV1, DENV2 became predominant in neighboring Malaysia. Dominance of DENV2 was most evident on the southern states where higher fatality rates were observed.
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