Publications by authors named "Yu-Jun Ruan"
Concise synthesis of 3--glycosyl isocoumarins and 2-glycosyl-4-chromen-4-ones.
Chem Commun (Camb)
September 2024
Article Synopsis
- A new catalytic method using Ruthenium (Ru) has been developed to create 3-glycosyl isocoumarins and 2-glycosyl-4-chromen-4-ones.
- This process involves the reaction of benzoic acid derivatives and 2-hydroxybenzaldehyde with carbonyl sulfoxonium ylide glycogen under mild conditions, yielding high-value glycosides.
- The reaction demonstrates versatility with diverse substrates and high compatibility with various functional groups, making it useful for large-scale synthesis and modifying complex natural products.
Article Synopsis
- New glyco-reagents based on carbonyl sulfoxonium ylides have been created for synthesizing C-glycosides, which are versatile molecules featuring sugar units.
- The synthesis process uses a Ru-catalyzed strategy that involves C-H activation/annulation and can handle various types of sugar donors.
- This advancement allows for more effective stereoselective production of complex heterocyclic C-glycosides and can be applied to large-scale manufacturing or modifications of natural products and pharmaceuticals.
Cp*Rh(III)-catalyzed regioselective cyclization of aromatic amides with allenes.
Chem Commun (Camb)
January 2024
A new Cp*Rh(III)-catalyzed regioselective cyclization reaction of aromatic amides with allenes is reported. The use of allenyl derivatives bearing a directing-group assistant as a reaction promoter was the key to the success of this protocol. In this catalytic system, -(pivaloyloxy)benzamide substrates react with allenes Rh-σ-alkenyl intermediates, while -(pivaloyloxy) indol substrates react Rh-π-allyl intermediates.
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- - This study explores a nickel-catalyzed method for glycosylation involving the removal of carboxyl and amino groups from activated aliphatic acids and amines.
- - The process successfully produces various alkyl-glycosides under simple and mild conditions, resulting in high yields.
- - The technique is versatile, allowing for the modification of complex natural products and drugs at later stages of their development.