Publications by authors named "Yu-Juan Jia"
Immunosenescence contributes to systematic aging and plays a role in the pathogenesis of Alzheimer's disease (AD). Therefore, the objective of this study was to investigate the potential of immune rejuvenation as a therapeutic strategy for AD. To achieve this, the immune systems of aged mice were rejuvenated through young bone marrow transplantation (BMT).
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- - Alzheimer's disease (AD) is a progressive brain disorder characterized by the accumulation of amyloid-β (Aβ) peptide plaques, which are seen as a major focus for developing treatments.
- - Despite past clinical trial failures targeting Aβ clearance, recent successful trials of lecanemab and donanemab support Aβ's role in AD and the potential for these therapies.
- - The analysis emphasizes the need for effective treatment strategies, including early intervention, sufficient Aβ removal, longer treatment durations, and possible combination therapies to improve cognitive outcomes in future AD trials.
Deficiencies in the clearance of peripheral amyloid β (Aβ) play a crucial role in the progression of Alzheimer's disease (AD). Previous studies have shown that the ability of blood monocytes to phagocytose Aβ is decreased in AD. However, the exact mechanism of Aβ clearance dysfunction in AD monocytes remains unclear.
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