Publications by authors named "Yu-Jie Mou"
The P2X7 receptor mediates NADPH transport across the plasma membrane.
Biochem Biophys Res Commun
December 2024
Article Synopsis
- NADPH is crucial for maintaining redox balance and biosynthesis, but its ability to cross cell membranes was unclear until now.
- This study shows that NADPH can be transported into cells through the P2X7 receptor, particularly in microglia, and this process is influenced by ATP and specific receptor antagonists.
- The findings suggest potential new methods for regulating NADPH levels, enhancing our understanding of its role in cellular processes like redox homeostasis and neuroinflammation.*
Cystathionine β-Synthase Suppresses NLRP3 Inflammasome Activation Redox Regulation in Microglia.
Antioxid Redox Signal
September 2023
Cystathionine β-synthase (CBS) is essential for homocysteine (Hcy) transsulfuration, yielding cysteine as a common precursor of hydrogen sulfide (HS), glutathione (GSH), and other sulfur molecules, which produce neuroprotective effects in neurological conditions. We previously reported a disruption of microglial CBS/HS signaling in a Parkinson's disease (PD) mouse model. Yet, it remains unclear whether CBS affects nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome activity and other pathologies in PD.
View Article and Find Full Text PDF