Supraspinal facilitation of painful stimuli by glutamatergic innervation from the retrosplenial to the anterior cingulate cortex.

The anterior cingulate cortex (ACC) is recognized as a pivotal cortical region involved in the perception of pain. The retrosplenial cortex (RSC), located posterior to the ACC, is known to play a significant role in navigation and memory processes. Although the projections from the RSC to the ACC have been found, the specifics of the synaptic connections and the functional implications of the RSC-ACC projections remain less understood.

Research on Lateral Stability Control of Four-Wheel Independent Drive Electric Vehicle Based on State Estimation.

This paper proposes a hierarchical framework-based solution to address the challenges of vehicle state estimation and lateral stability control in four-wheel independent drive electric vehicles. First, based on a three-degrees-of-freedom four-wheel vehicle model combined with the Magic Formula Tire model (MF-T), a hierarchical estimation method is designed. The upper layer employs the Kalman Filter (KF) and Extended Kalman Filter (EKF) to estimate the vertical load of the wheels, while the lower layer utilizes EKF in conjunction with the upper-layer results to further estimate the lateral forces, longitudinal velocity, and lateral velocity, achieving accurate vehicle state estimation.

Design of integrated radar and communication system based on solvable chaotic signal.

In the integrated radar and communication system (IRCS), the design of signal that can simultaneously satisfy the radar detection and communication transmission is very important and difficult. Recently, some new properties of a class of solvable chaotic system have been studied for wireless applications, such as low bit error rate (BER) wireless communications and low cost target detection. In this paper, a novel IRCS based on the chaotic signal is proposed, and the performance of proposed scheme is analyzed.

Study on energy evolution and fractal characteristics of sandstone with different fracture dip angles under uniaxial compression.

In order to investigate the failure modes and instability mechanism of fractured rock. Uniaxial compression tests were conducted on sandstone specimens with different dip angles. Based on rock energy dissipation theory and fractal theory, the energy evolution characteristics and fragmentation fractal characteristics in the process of deformation and failure of specimens were analyzed.

Alkylide derivatives of diphyllin: synthesis and preliminary anticancer evaluation.

Fourteen diphyllin 4--substituted alkylide derivatives were designed and synthesized using a Heck coupling and subsequent hydrogenation reaction. Olefins and exhibited the highest cytotoxicity on breast cancer cell lines MCF-7 with IC values of 0.08 and 0.

The Regulatory Mechanism of Hypoxia-inducible Factor 1 and its Clinical Significance.

Hypoxia-inducible factor (HIF) is a nuclear protein that plays a crucial role in oxygen homeostasis through its transcriptional activity and thousands of target gene profiles. Through transcriptional and post-transcriptional regulation, the downstream target genes of HIF can trigger multiple pathological responses in the body, including energy metabolism, cytopenia, and angiogenesis. There are three distinct subtypes of HIF: HIF-1, HIF-2, and HIF-3.

[Multi-component content determination of Dracocephalum tanguticum by quantitative analysis of multi-components by single-marker].

This study aims to establish a method for the simultaneous determination of 7 active components in Dracocephalum tanguticum and to evaluate the quality of medicinal materials from different habitats. The method was established with high performance liquid chromatography(HPLC) and the gradient elution was performed with the mobile phase of acetonitrile-methanol-0.2% phosphoric acid solution at a column temperature of 35 ℃, an injection volume of 15 μL, and a flow rate of 0.

Clinical Effect of Modified Ultrasound-Guided Subclavian Vein Puncture.

Objective: This study compared the effect of ultrasound-guided subclavian vein puncture with traditional blind puncture and the double-screen control method by evaluating the one-time puncture success and total success rates, the completion time for puncture and catheterization, and short-term complications.

Methods: From January 2020 to January 2021, 72 patients with right subclavian venipuncture catheterization were collected, 12 of whom were excluded (including 3 cases of pneumothorax, 2 cases of hemothorax, 1 case of difficult positioning of thoracic deformity, 1 case of severe drug eruption, 3 cases of clavicle fracture, and 1 case of severe coagulation dysfunction). The remaining 60 cases were randomly divided into the traditional group ( = 30) and the improved group ( = 30).

The design and application of an intensive care unit point-of-care nursing handover checklist based on the situation, background, assessment, and recommendation technique.

Objective: This study aims to analyze the effect of using an intensive care unit point-of-care nursing handover checklist based on the situation, background, assessment, and recommendation (SBAR) communication technique.

Methods: An intensive care unit point-of-care nursing handover checklist was designed based on the SBAR technique, and standard point-of-care nursing handover procedures and effect assessment indicators were established to compare the occurrence of adverse handover events and nursing risks with those previously observed.

Results: Before and after the application of the intensive care unit point-of-care SBAR checklist, the occurrence of missed items during the handover was 7.

Baishideng's database announces the first of 101 core journals and a list of high-quality academic journals in gastroenterology and hepatology.

After three rounds of rigorous evaluation of core journals in gastroenterology and hepatology conducted by the () editorial team of Baishideng Publishing Group (Baishideng), the database of Baishideng officially released the 2022 (2022 ) of 101 core journals in gastroenterology and hepatology, for the first time. The list of 101 core journals can be found at: https://www.referencecitationanalysis.

Baishideng's database announces the first of 104 core journals and a list of high-quality academic journals in orthopedics.

After three rounds of rigorous evaluation of core journals in orthopedics conducted by the () editorial team of Baishideng Publishing Group (Baishideng), the database of Baishideng officially released the 2022 (2022 ) of 104 core journals and a list of high-quality academic journals in orthopedics, for the first time on August 9, 2022. The list of 104 core journals can be found at: https://www.referencecitationanalysis.

Baishideng's database announces the first of multidisciplinary scholars.

After three rounds of rigorous evaluation of registered scholars conducted by the () editorial team of Baishideng Publishing Group (Baishideng), the database of Baishideng officially released the 2022 (2022 ) of 632 scholars from 74 countries/territories in 98 research categories, for the first time. The list of 632 scholars can be found at: https://www.referencecitationanalysis.

Efficacy of Pretreatment with Polysaccharide in Various Doses in Influencing Splenic Immunity and Prognosis of Sepsis in Rats.

Objective: Sepsis, showing high mortality, is a lethal dysfunction of organs caused by an infection-induced disorder in the host response. It has complicated pathogenesis, which has not yet been elucidated completely. Recently, the principal factors causing pathogenesis and even death in sepsis patients are imbalance in inflammatory response and immunosuppression occurring when the host is challenged by infection.

Acute methanol poisoning with bilateral diffuse cerebral hemorrhage: A case report.

Background: Acute methanol poisoning (AMP) is a systemic disease that mainly affects the central nervous system and is characterized by ocular damage and metabolic acidosis. If appropriate treatments are inadequate or delayed, the mortality can exceed 40%. As the most serious complication, cerebral hemorrhage is rare with reported prevalence of 7%-19%.

TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway.

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and major cause of cancer death in the world. Ferroptosis is a recently identified type of regulated cell death. Increasing evidence has shown that ferroptosis plays an important regulatory role in the occurrence and development of cancer.

The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related Symptoms and Side-Effects.

In addition to cancer-related death, malignant progression also leads to a series of symptoms and side-effects, which would detrimentally affect cancer patients' the quality of life, adversely influence their adherence to treatments, and, therefore, negatively affect their long-term survival. Acupuncture and electroacupuncture (EA), as two classic treatment methods in traditional Chinese medicine, have been widely employed to cure various diseases. Recently, the clinical application of acupuncture and EA in cancer patients has received great attention.

[Applicability of thermal dissipation probe in the determination of trunk flow of under cyclic heating mode].

To evaluate the adaptability of the cyclic heating mode in the thermal diffusion probe method (TDP) in the measurement of trunk sap flow and the accuracy of the measurement of tree transpiration water consumption, we selected as the research object and set three different heating modes: 60 min/0 min (continuous heating mode), 30 min/30 min (cyclic heating mode with 30 min heating and 30 min cooling), 10 min/50 min (cyclic heating mode with 10 min heating and 50 min cooling). Based on the measured value of the whole tree container wei-ghing method, the temperature gradient characteristics of different heating modes were analyzed using the measurement technology of thermal diffusive trunk sap flow. The Granier's corrected formulas of cyclic heating modes were constructed, with its error being analyzed by validity verification.

[Adaptability of Granier empirical formula in sap flow measurement of Populus tomentosa based on whole tree weighing method].

We evaluated the adaptability of Granier's empirical formula in the measurement of trunk sap flow in Populus tomentosa. The thermal diffusion probe method (TDP) was used to mea-sure sap flow rate, and the whole tree weighing was simultaneously measured for each tree. We compared results from the Granier empirical formula with that from the whole tree weighing to find out whether Granier formula had any error in measuring the trunk sap flow of P.

Extension of C. elegans lifespan using the ·NO-delivery dinitrosyl iron complexes.

The ubiquitous and emerging physiology function of endogenous nitric oxide in vascular, myocardial, immune, and neuronal systems prompts chemists to develop a prodrug for the controlled delivery of ·NO in vivo and for the translational biomedical application. Inspired by the discovery of natural [Fe(NO)] motif, herein, we develop the synthetic dinitrosyl iron complexes (DNICs) [Fe(μ-SR)(NO)] (1) as a universal platform for the O-triggered release of ·NO, for the regulation of ·NO-release kinetics (half-life = 0.6-27.

Reduced-dose EPOCH-R chemotherapy for elderly patients with advanced stage diffuse large B cell lymphoma.

The standard treatment in elderly patients with diffuse large B cell lymphoma (DLBCL) has not yet been finely established. We investigated the efficacy and safety of rituximab with a reduced-dose of EPOCH chemotherapy in elderly patients who had advanced DLBCL with high IPI scores. The dose of 70% EPOCH was given to patients aged 75 to 79 years, and dose of 50% to patients aged over 80 years.

High-dose methotrexate, etoposide, dexamethasone and pegaspargase (MEDA) combination chemotherapy is effective for advanced and relapsed/refractory extranodal natural killer/T cell lymphoma: a retrospective study.

Extranodal natural killer/T cell lymphoma, nasal type (ENK/TCL), is an aggressive and rare hematological malignancy. Patients with advanced and relapsed/refractory disease have very poor outcomes. In this study, we retrospectively assessed the efficacy and safety of MEDA regimen (methotrexate, etoposide, dexamethasone and pegaspargase) in the treatment of advanced and relapsed/refractory ENK/TCL patients.

[Promoting effect of thrombin on proliferation of bone marrow-derived mesenchymal stem cells and its mechanisms].

This study was aimed to investigate the growth-promoting activity of thrombin on mesenchymal stem cells (MSC) and its mechanisms. Human bone marrow MSC were cultured in serum-free medium supplemented with graded concentrations of thrombin, and the proliferation status of MSC was detected by MTT test. The expression levels of protease-activated receptors (PAR) and c-MYC gene were detected by PCR.

Comparison of flavonoids, phenolic acids, and antioxidant activity of explosion-puffed and sun-dried jujubes (Ziziphus jujuba Mill.).

The goal of the present study was to investigate the effect of explosion puffing and sun-drying on individual phenolic acids in four forms (free, esters, glycosides, and insoluble-bound), flavonoids, total phenolic content (TPC), and their antioxidant activity on jujube samples. Phenolic compounds were identified and quantified using high-performance liquid chromatography. Antioxidant capacity of jujube samples was evaluated by 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity and total reducing power.