The mechanism and relevant mediators associated with neuronal apoptosis and potential therapeutic targets in subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) is a dominant cause of death and disability worldwide. A sharp increase in intracranial pressure after SAH leads to a reduction in cerebral perfusion and insufficient blood supply for neurons, which subsequently promotes a series of pathophysiological responses leading to neuronal death. Many previous experimental studies have reported that excitotoxicity, mitochondrial death pathways, the release of free radicals, protein misfolding, apoptosis, necrosis, autophagy, and inflammation are involved solely or in combination in this disorder.

Development and design validation of a novel network meta-analysis presentation tool for multiple outcomes: a qualitative descriptive study.

Objective: The Grades of Recommendations, Assessment, Development and Evaluation working group recently developed an innovative approach to interpreting results from network meta-analyses (NMA) through minimally and partially contextualised methods; however, the optimal method for presenting results for multiple outcomes using this approach remains uncertain. We; therefore, developed and iteratively modified a presentation method that effectively summarises NMA results of multiple outcomes for clinicians using this new interpretation approach.

Design: Qualitative descriptive study.

Improved Doping and Optoelectronic Properties of Zn-Doped Cspbbr Perovskite through Mn Codoping Approach.

Reducing the toxic Pb component in perovskites is an important step to realize environment-friendly perovskite optoelectronic devices. Herein, the structural, electronic, and optical properties of Zn and Mn codoped CsPbBr have been investigated based on first-principle calculations and experimental verifications. Although the Zn dopant could reduce the optical band gap and exciton binding energy and enhance the optical absorption and defect tolerance for CsPbBr, the maximum reduction of the toxic Pb component was just about 12.

HNF-1 binding point mutation of the AFP gene promotes cirrhosis in post-menopausal women.

Objective: α-fetoprotein (AFP) expression is activated during the embryonic stage or hepatocellular carcinogenesis, so it is presumed that AFP is a key endogenous molecule to promote cell proliferation or differentiation. We carried out gene screening in an unknown family with hyper-alpha-fetoproteinemia and some sporadic menopausal women, and discussed the relationship between AFP expression and liver cirrhosis.

Methods: Peripheral blood samples from family members, patients with malignant liver tumors, and normal controls were collected.

[An integrated method works well on varicocele].

Objective: To assess an integrated method of operation + Chinese medicine + dexamethasone + vitamin E in treating varicocele.

Methods: Ninety-six patients with varicocele were randomly divided into two groups, the experimental group (Group A, n=47) treated with the integrated method, the control group (Group B, n=49) treated with Chinese medicine, dexamethasone and vitamin E.

Results: After the treatment, the sperm density and motility and pregnancy rate were higher (P < 0.