Publications by authors named "Yu-Hui Gu"
Introduction: Due to different social and cultural backgrounds, cervical cancer patients' experience of the treatment process and quality of life after treatment will be different. This study sought to gain in-depth understanding of the experiences of Chinese cervical cancer patients as regards their quality of life and physical symptoms.
Methodology: Semi-structured interviews were used to collect data.
Atrial fibrillation (AF), the most common cardiac arrhythmia, is an important contributor to mortality and morbidity. Ubquitin-specific protease 7 (USP7), one of the most abundant ubiquitin-specific proteases (USP), participated in many cellular events, such as cell proliferation, apoptosis, and tumourigenesis. However, its role in AF remains unknown.
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- * Research shows that USP7 levels rise in heart failure cases, and inhibiting it with p22077 reduces heart enlargement, fibrosis, inflammation, and oxidative stress.
- * The study finds that p22077 works by interfering with several signaling pathways in the heart, suggesting that USP7 could be a potential target for treating heart hypertrophy and failure.
Article Synopsis
- * In a mouse model of AF induced by angiotensin II (Ang II), researchers found that Bhlhe40 levels increased in cardiomyocytes and atrial tissues, indicating its potential involvement in AF pathology.
- * Knocking down Bhlhe40 specifically in heart tissues reduced Ang II-induced atrial changes and AF characteristics, suggesting that Bhlhe40 could be a new target for treating heart conditions like hypertrophic remodeling and heart failure.