Photoresponsive smart template for reversible cell micropatterning.

A novel micropatterned smart template based on transparency photolithography allows the spatial control of cell micropatterning. By utilizing the photoinduced reaction of azobenzene ligands and cyclodextrin-terminated alkanesilane via host-guest recognitions, cells can be easily controlled to adhere reversibly in well defined areas.

PEGylated peptide based reductive polycations as efficient nonviral gene vectors.

To overcome the critical barriers in gene delivery, a series of reducible polycations (RPCs) based on low molecular weight (LMW) peptides, i.e. PolyHK6 H, PolyHK6 H-mPEG1 , PolyHK6 H-mPEG2 , and PolyHK6 H-mPEG3 , with different poly(ethylene glycol) (PEG) contents, are synthesized and evaluated as nonviral gene vectors.

Encapsulation of an adamantane-doxorubicin prodrug in pH-responsive polysaccharide capsules for controlled release.

Supramolecular microcapsules (SMCs) with the drug-loaded wall layers for pH-controlled drug delivery were designed and prepared. By using layer-by-layer (LbL) technique, the SMCs were constructed based on the self-assembly between polyaldenhyde dextran-graft-adamantane (PAD-g-AD) and carboxymethyl dextran-graft-β-CD (CMD-g-β-CD) on CaCO(3) particles via host-guest interaction. Simultaneously, adamantine-modified doxorubicin (AD-Dox) was also loaded on the LbL wall via host-guest interaction.