Publications by authors named "Yu-Huang Liao"
Hepatic lipase (encoded by ) is a glycoprotein in the triacylglycerol lipase family and mainly synthesized in and secreted from the liver. Previous studies demonstrated that hepatic lipase is crucial for reverse cholesterol transport and modulating metabolism and the plasma levels of several lipoproteins. This study was conducted to investigate the suppression effect of high-density lipoprotein cholesterol (HDL-C) levels in a genome-wide association study and explore the possible mechanisms linking triglyceride (TG) to variants and HDL-C.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly evolved into a global pandemic. The hyperglycemia in patients with diabetes mellitus (DM) substantially compromises their innate immune system. SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) receptors to enter the affected cell.
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- Galectin-3 is important for regulating inflammation, and this study aimed to explore the link between LGALS3 genotypes, galectin-3 levels, and inflammation in coronary artery disease (CAD) patients.
- In a study with 474 patients, significant correlations were found between galectin-3 levels and various inflammatory markers, with specific LGALS3 genotypes strongly associated with galectin-3 levels.
- The findings indicate that while galectin-3 levels are influenced by genetic factors, these genotypes do not directly affect the levels of other inflammatory markers, suggesting more research is needed to understand galectin-3's role in chronic inflammatory diseases.
Effects of tea consumption and the interactions with lipids on breast cancer survival.
Breast Cancer Res Treat
August 2019
Purpose: The effect of tea consumption on breast cancer survival remained to be explored. Meanwhile, green tea favorably facilitates lipid metabolisms in breast cancer survivors. This study aimed to examine the effect of tea consumption and the interactions with lipids on breast cancer survival.
View Article and Find Full Text PDFPurpose: This study differentiates patient and care delays of breast cancer and explores the related factors as well as the associations with the prognosis in Guangzhou, a southern city of China.
Methods: A cohort of female incident breast cancer patients (n=1,551) was recruited from October 2008 to March 2012 and followed up until January 1, 2016 (n=1,374) in the affiliated hospitals of Sun Yat-sen University. The factors associated with patient and care delays were analyzed with multivariable logistic models.
Background: In Guangzhou, China, colorectal cancer (CRC) is the second most commonly diagnosed cancer. The government initiated a CRC screening program in 2015, and investigating the knowledge, attitudes, and practices toward CRC would help facilitate the participation of the program. Methods: A cross-sectional survey was conducted from October 2014 to September 2015.
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- The study found a link between IgA antibodies of Epstein-Barr virus and breast cancer (BC), specifically relating certain genetic markers in homologous recombination repair (HRR) genes to BC risk and survival.
- A case-control study involving 1551 BC patients and 1605 healthy controls was conducted in China, focusing on five specific genetic variations to evaluate their impact on BC risk and prognosis.
- Key findings included an increased BC risk associated with the RFC1 gene variant, while the NRM gene variant correlated with worse progression-free survival and the LIG3 variant with better survival, indicating varying effects of HRR gene polymorphisms on BC outcomes.