Publications by authors named "Yu-Huang Li"
Article Synopsis
- p53 is a crucial tumor suppressor protein that helps regulate the cell cycle, apoptosis, and DNA repair, but its degradation is primarily controlled by MDM2, a protein that is often overexpressed in human cancers, leading to reduced p53 function.
- Researchers are attempting to develop MDM2 antagonists to stabilize and activate p53 for cancer therapy, but previous efforts have faced challenges due to the toxic effects of these compounds.
- This study successfully identified a new compound, CGMA-Q18, through virtual screening, which binds to MDM2, activates p53, induces cancer cell death, and shows promise in suppressing tumor growth in mice without noticeable toxicity.
Aim: To explore the efficacy of PCI-24781, a broad-spectrum, hydroxamic acid-derived histone deacetylase inhibitor, in the treatment of gastric cancer (GC).
Methods: With or without treatment of PCI-24781 and/or cis-diamminedichloroplatinum (CDDP), GC cell lines were subjected to functional analysis, including cell growth, apoptosis and clonogenic assays. Chromatin immunoprecipitation and luciferase reporter assays were used to determine the interacting molecules and the activity of the enzyme.