Publications by authors named "Yu-Hao Wan"
Article Synopsis
- A study investigated the link between low transthyretin (prealbumin) levels and mortality or hospital readmissions among elderly inpatients, enrolled between September 2018 and April 2019 in Beijing.
- A total of 636 elderly participants were analyzed, and it was found that those with low transthyretin levels (below the 5th percentile) had more than double the risk (hazard ratio 2.25) of dying or being readmitted compared to those with normal levels.
- The study concluded that low transthyretin concentration is an independent risk factor for poor outcomes in elderly men, but this correlation was not observed in elderly women.
Background: Frailty increases the adverse outcomes of clinical heart failure; however, the relationship between frailty and stage-B heart failure (SBHF) remains unknown. We aimed to explore the epidemiology and predictive value of frailty in older adults with SBHF.
Methods: A prospective cohort of SBHF inpatients aged 65 years or older who were hospitalized between September 2018 and February 2019 and were followed up for 6 months were included.
Objective: Chronic inflammation is associated with major adverse cardiovascular events (MACEs), mortality, and frailty. Our aim was to add high-sensitivity C-reactive protein (hsCRP) to the frailty assessment to predict its association with prognosis of older adults with cardiovascular disease (CVD).
Methods: A comprehensive geriatric assessment was conducted at baseline in 720 in-patients aged ≥65 years with CVD.
To evaluate the prognostic value of frailty in gerontal pre-clinical heart failure (stage B heart failure, SBHF) inpatients. The association between frailty and SBHF remains unknown. We conducted a subgroup analysis of a prospective observational cohort study on frailty.
View Article and Find Full Text PDFBackground: We aimed to assess the utility of the combination of the mini-mental state examination (MMSE) + clock drawing test (CDT) and the Fried phenotype for predicting non-elective hospital readmission or death within 6 months in elderly inpatients with cardiovascular disease (CVD).
Methods: A single-center prospective cohort was conducted from September 2018 to February 2019. Inpatients ≥65 years old were recruited.
The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) in urine are two aging biomarkers that have not been explored deeply in cases of frailty. A total of 508 elderly patients with cardiovascular disease (mean age 75.
View Article and Find Full Text PDF