Publications by authors named "Yu-Hao Liao"
Article Synopsis
- Extranodal extension (ENE) is included in the cancer staging for hypopharyngeal squamous cell carcinoma (HypoSCC), but its effects on survival rates and treatment effectiveness are not fully understood.
- A study of 388 HypoSCC patients revealed that those with ENE had much lower 5-year overall survival rates (22.9% with radiological ENE and 40.3% with pathological ENE) compared to those without ENE (55.5%).
- The research suggests that ENE is a significant risk factor for poorer survival outcomes, and that upfront neck dissection can improve disease-free survival and control in both ENE+ and ENE- patients.
Immunotherapy has revolutionized cancer treatment, but the lack of a reliable predictive biomarker for treatment response remains a challenge. Alpha-1,6-Mannosylglycoprotein 6-β-N-Acetylglucosaminyltransferase 5 (MGAT5) is a key regulator of complex N-glycan synthesis, and its dysregulation is associated with cancer progression. The lectin Phaseolus vulgaris leukoagglutinin (PHA-L) specifically binds to mature MGAT5 products.
View Article and Find Full Text PDFBackground: Oral cancer causes significant morbidity and mortality. Chemoprevention utilizes medication or natural compounds to reverse oral premalignant lesions and to prevent second primary tumors.
Methods: A comprehensive PubMed database and Cochrane Library search from 1980 to 2021 was performed using the keywords "leukoplakia," "oral premalignant lesion," and "chemoprevention.
Article Synopsis
- Radiation-induced sarcoma of the head and neck (RISHN) is a rare but serious complication following radiotherapy for head and neck cancer, prompting a study to analyze its characteristics and molecular traits.
- The study examined 24 patients treated between 1994 and 2019, assessing demographics, tumor staging, risk factors, and survival rates, with whole-exome sequencing (WES) conducted on select samples.
- Findings revealed a median RISHN diagnosis age of 54 years, with risk factors including oral cavity primary cancer and certain lifestyle choices; insights from WES highlighted key genetic pathways linked to the disease, emphasizing the need for awareness and early detection to improve patient outcomes.
Predicting secondary endolymphatic hydrops in patients with noise-induced hearing loss.
Acta Otolaryngol
February 2022
Background: Long-term noise exposure may damage the cochlea and endolymph resorption system, which induces episodic vertigo and/or fluctuating hearing loss in later years.
Objective: This study adopted clinical symptoms, inner ear test battery, and/or magnetic resonance (MR) imaging to evaluate development of secondary endolymphatic hydrops (EH) in patients with noise-induced hearing loss (NIHL).
Methods: Forty NIHL patients with secondary EH were assigned to Group A.
Firecrackers are still popular among the general public of various populations worldwide. This study investigated inner ear damage in patients with firecracker trauma and analyzed noise levels in 6 kinds of commercially available firecrackers. During the past 20 years, we have experienced 30 patients with firecracker trauma.
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