Publications by authors named "Yu-Han Pu"
In recent years, studies have demonstrated that vascular endothelial growth factor B (VEGFB) can affect the metabolism of fatty acids and glucose, and it is expected to become a target for the diagnosis and treatment of metabolic diseases such as obesity and diabetes. At present, the specific mechanism that VEGFB regulates lipid and glucose metabolism balance is not completely understood. The present study used systemic VEGFB gene‑knockout mice to investigate the effects of downregulation of the VEGFB gene on lipid metabolism and insulin secretion, and to explore the mechanism of the VEGFB pathway involved in the regulation of glucose and lipid metabolism.
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- Researchers used a genetic dereplication method and differential gene expression to discover three new compounds called tricinoloniol acids (TRAs) A-C and a known compound, fusidilactone A, from the fungus T. hypoxylon.
- They performed a transcriptomic analysis and targeted deletion to map out the biosynthetic pathway for TRAs.
- The study highlights a new way to apply genetic dereplication to find hidden secondary metabolites by examining the coordinated expression of specific gene clusters.