Detection of clarithromycin-resistant Helicobacter pylori in clinical specimens by molecular methods: A review.

Various molecular methods have been developed to rapidly detect clarithromycin (CLR) resistance in Helicobacter pylori isolates in clinical specimens. All of these assays for detecting CLR resistance in H. pylori are based on detection of mutations in the 23S rRNA gene.

Overexpression of integrin αv in the human nasopharyngeal carcinoma associated with metastasis and progression.

Background: Integrins are cell-surface adhesion molecules, regulate normal cellular interactions, and which are consisting of α and β subunits and facilitate signal transduction in a bidirectional manner. Tumor cells have been found to express a wide variety of integrins, overexpression of integrin αv has been detected in a growing number of human malignancy types, However, the reports obout expression of integrin αv in nasopharyngeal carcinoma (NPC) are very rare.

Objective: This study aims to detect the expression of integrin αv in NPC, and to evaluate the correlation between integrin αv expression and clinicopathological factors.

Enzymic colorimetry-based DNA chip: a rapid and accurate assay for detecting mutations for clarithromycin resistance in the 23S rRNA gene of Helicobacter pylori.

Macrolide drugs, such as clarithromycin (CAM), are a key component of many combination therapies used to eradicate Helicobacter pylori. However, resistance to CAM is increasing in H. pylori and is becoming a serious problem in H.