Publications by authors named "Yu-Fen Meng"
Article Synopsis
- Gastric intestinal metaplasia (GIM) is a significant precursor to gastric cancer, and the traditional Chinese medicine Huangqi Jianzhong decoction (HQJZ) shows promise for treating patients with cold intolerance, though the underlying mechanisms are unclear.
- The study aimed to understand how HQJZ affects GIM through the gut microbiota‒thyroid axis using a rat model, assessing tissue lesions and serum metabolites.
- Results revealed that HQJZ improved gastric and thyroid conditions, enhanced cold tolerance, increased beneficial gut bacteria, and reduced harmful metabolites, indicating its potential therapeutic mechanisms involving butyric acid.
[Listeria-induced host cellular actin cytoskeleton rearrangement and phospholipase D].
Wei Sheng Wu Xue Bao
October 2006
Either phagocytosis of macrophage to pathogen or pathogen-induced invasion into non-professional phagocytes, such as epithelial cells, require actin cytoskeletal rearrangements and remodeling of the plasma membrane, which are regulated precisely by monogeric GTPase and the correlated proteins. As a key signaling molecule in the cell, phosphotidicphospholipase D (PLD) regulates or interacts directly with cellular actin cytoskeleton rearrangement. Phospholipase D plays an important role in FcgammaRI and C-reactive protein-mediated phagocytosis and phosphorylated cofilin, a ADF (actin depolymerizing factor) is able to bind to phospholipase D and stimulate it; meanwhile, the Listeria-induced actin cytoskeleton rearrangement during the infection is controlled by the phosphorylation of cofilin.
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