Novel endogenous angiogenesis inhibitors and their therapeutic potential.

Angiogenesis, the formation of new blood vessels from the pre-existing vasculature is essential for embryonic development and tissue homeostasis. It also plays critical roles in diseases such as cancer and retinopathy. A delicate balance between pro- and anti-angiogenic factors ensures normal physiological homeostasis.

The effectiveness of essential oils for patients with neck pain: a randomized controlled study.

Objectives: To assess the efficacy of aromatic essential oils on neck pain.

Design: Sixty participants with a history of neck pain and Neck Disability Index (NDI) score >10% were selected and randomly divided into control and experimental groups.

Setting: Motion analysis laboratory at Hungkuang University.

Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes.

The orchestration of histone modifiers is required to establish the epigenomic status that regulates gene expression during development. Whsc1 (Wolf-Hirschhorn Syndrome candidate 1), a histone H3 lysine 36 (H3K36) trimethyltransferase, is one of the major genes associated with Wolf-Hirshhorn syndrome, which is characterized by skeletal abnormalities. However, the role of Whsc1 in skeletal development remains unclear.