Publications by authors named "Yu-Fang Xiong"
Objective: Endometriosis is an estrogen-dependent disease, a steroid receptor-binding protein bearing the regulator of the G-protein signaling domain (SRB-RGS) can suppress the estrogen receptors-mediated transcriptional activities. We sought to determine whether overexpression of SRB-RGS suppresses the migration and invasion ability of endometrial stromal cells stimulated by 17β-estradiol (E2).
Study Design: Endometrial stromal cells were obtained from endometriosis patients.
Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats.
World J Gastroenterol
July 2015
Aim: To investigate the therapeutic effects of lutein against non-alcoholic fatty liver disease (NAFLD) and the related underlying mechanism.
Methods: After 9 d of acclimation to a constant temperature-controlled room (20 °C-22 °C) under 12 h light/dark cycles, male Sprague-Darley rats were randomly divided into two groups and fed a standard commercial diet (n = 8) or a high-fat diet (HFD) (n = 32) for 10 d. Animals receiving HFD were then randomly divided into 4 groups and administered with 0, 12.
Article Synopsis
- Three novel alkaloids were isolated from the bulbs of Lycoris longituba, along with nineteen known ones, and their structures were determined using spectroscopic analysis.
- For the first time, harmane-type alkaloids were identified in the Lycoris genus among the new and known compounds.
- The isolated alkaloids showed varying neuroprotective effects against specific cell injuries and significant acetylcholinesterase (AChE) inhibition, particularly in compounds 12, 14-20, and 22.
Article Synopsis
- Previous research shows calyculin A (CA) disrupts axonal transport in neuroblastoma cells and is linked to Alzheimer-like symptoms, but melatonin can counteract these effects.
- In this study, melatonin was found to protect neuroblastoma N2a cells from CA-induced toxicity, hyperphosphorylation of proteins, and aid in maintaining cell metabolism and viability.
- Additionally, melatonin partially reversed the phosphorylation of a key site on PP-2A, indicating it may help restore normal function and reduce oxidative stress markers, thus improving axonal transport affected by CA.
Objective: To explore a new method for the therapy of avascular necrosis of the femoral head.
Method: The recombinant plasmid pCD-rbFGF was mixed with collagen and was implanted in the necrotic femoral head. Expression of basic fibroblast growth factor (bFGF) was examined by RT-PCR and immunohistochemical method.