Two new iridoid glycosides from the fruit of .

Two new iridoid glycosides, 2'---coumaroylgardoside (), and 6'--caffeoylioxide (), were isolated from the fruit of . The structures of these compounds were elucidated based on spectroscopic analysis (HR-ESI-MS, NMR) and chemical methods. The anti-inflammatory activities of the isolates were evaluated by measuring their inhibitory effects on PGE production in LPS stimulated RAW 264.

A new nitrogen-containing iridoid glycoside from .

A new nitrogen-containing iridoid glycoside, named (7 ,3'-lonijapospiroside A (), together with thirteen known iridoid glycosides, were isolated from the flower buds of . The structures of these compounds were established on the basis of spectroscopic analyses. Among them, compounds are four diastereoisomers, and their absolute configurations were accurately established by the NOE spectra as well as comparison of their experimental and calculated ECD spectra.

Three new cycloart-7-ene triterpenoid glycosides from and their anti-inflammatory effects.

Ten cycloart-7-ene triterpenoid glycosides, including three new compounds (-), were isolated from the roots of . Their structures were elucidated on the basis of extensive spectroscopic analyses, chemical methods and comparison with literatures. In addition, the isolates were evaluated for their inhibitory effects on the production of NO, as well as the expressions of iNOS and COX-2 in LPS-stimulated RAW 264.

Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities.

The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid (1) and 2α, 4α-dihydroxy-23-nor-ursolic acid (2).

A new hetero dimeric terpenoid derivative, japonicaside C, from the flower buds of Lonicera japonica.

A rare hetero dimeric terpenoid derivative, named japonicaside C, together with five known secoiridoid gloucosides were isolated from the flower buds of Lonicera japonica. The structures of these compounds were established on the basis of spectroscopic analyses. Japonicaside C is the first representative of a novel type of hetero dimeric terpenoid, biogenetically originated from a guaiane-type sesquiterpenoid and a secoiridoid glucoside.

Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives.

Factor IXa (FIXa), a blood coagulation factor, is specifically inhibited at the initiation stage of the coagulation cascade, promising an excellent approach for developing selective and safe anticoagulants. Eighty-four amidinobenzothiophene antithrombotic derivatives targeting FIXa were selected to establish three-dimensional quantitative structure-activity relationship (3D-QSAR) and three-dimensional quantitative structure-selectivity relationship (3D-QSSR) models using comparative molecular field analysis and comparative similarity indices analysis methods. Internal and external cross-validation techniques were investigated as well as region focusing and bootstrapping.