Publications by authors named "Yu-Dan Ding"
Article Synopsis
- The study investigates the nucleus accumbens (NAc), which is key in reward processing and its role in major depressive disorder (MDD).
- Through meta- and mega-analysis of resting-state fMRI data, it was found that patients with recurrent MDD exhibited decreased functional connectivity within the NAc-based reward circuits.
- The research highlights that disrupted connectivity between the reward network and the default mode network (DMN) may aid in differentiating MDD patients from healthy individuals, suggesting potential biomarkers for diagnosis.
Article Synopsis
- The study investigates brain functional connectivity asymmetry in patients with Major Depressive Disorder (MDD) using resting-state fMRI data from 753 patients compared to 451 healthy controls.
- Results show that MDD patients exhibited increased asymmetry scores, indicating decreased specialization in various brain networks, particularly in the default mode, control, and attention networks, influenced by demographic and clinical variables.
- The findings suggest that MDD disrupts efficient brain information processing, providing new insights into the pathophysiology of depression that could inform future research.
Increased frontal gray matter volume in individuals with prodromal psychosis.
CNS Neurosci Ther
September 2019
Article Synopsis
- The study investigates brain anatomical deficits in individuals showing early signs of psychosis (prodromal individuals) compared to healthy controls.
- Using MRI scans, the researchers found that prodromal individuals had increased gray matter volume in certain frontal brain areas, specifically the right inferior frontal gyrus and right rectus gyrus.
- Although these increased gray matter volumes did not correlate with clinical or cognitive features, they showed potential as markers for distinguishing prodromal individuals from healthy controls, emphasizing the role of the frontal regions in psychosis development.