Publications by authors named "Yu-Chi Chuang"
SLC26A4 encodes pendrin, a crucial anion exchanger essential for maintaining hearing function. Mutations in SLC26A4, including the prevalent c.919-2 A > G splice-site mutation among East Asian individuals, can disrupt inner ear electrolyte balance, leading to syndromic and non-syndromic hearing loss, such as Pendred syndrome and DFNB4.
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- Researchers studied lung adenocarcinomas (LUAD) in non-tobacco users to find new genetic drivers of lung cancer, identifying 21 positively selected genes, including 12 that are novel in this context.* -
- One particularly important find was the SHPRH gene, which showed a link between low expression levels and poor survival outcomes in LUAD patients, indicating its potential role as a tumor suppressor.* -
- Reintroducing SHPRH in LUAD cell lines diminished tumor growth and the ability to form colonies, suggesting it’s critical for resistance against DNA damage, which could help predict patient responses to treatments.*
Background: Induction of apoptosis by endoplasmic reticulum (ER) stress is implicated as the major factor in the development of multiple diseases. ER stress also appears to be a potentially useful major response to many chemotherapeutic drugs and environmental chemical compounds. A previous study has indicated that one major apoptotic regulator, p53, is significantly increased in response to ER stress, and participates in ER stress-induced apoptosis.
View Article and Find Full Text PDFMany of the promising applications of the microarray technology are pertinent to identifying abnormalities in gene expression that contribute to malignant progression. We developed a bioinformatics tool to identify differentially expressed genes in human hepatocellular carcinoma (HCC). This involved the construction of a liver EST database (http://lestdb.
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