Investigate the potential impact of Hemagglutinin from the H1N1 strain on severe pneumonia.

The most prevalent glycoprotein on the influenza virus envelope is called hemagglutinin (HA), yet little is known about its involvement in the pathophysiology and etiology of severe influenza pneumonia. Here, after stimulating human bronchial epithelial cells (16-HBE) and mice with HA of H1N1 for 12 h, we investigated the proliferation, migration, inflammatory cytokines expression, and apoptosis in 16-HBE and the pathological damage in mouse lung tissue. The expression of inflammatory cytokines plasminogen activator inhibitor 1(PAI-1), urokinase-type (uPA) and tissue-type (tPA) plasminogen activators, and apoptosis were all enhanced by HA, which also prevented the proliferation and migration of bronchial epithelial cells.

[Effect of malaria control in Shayang County from 1995 to 2014].

Objective: To evaluate the effect of malaria control in Shayang County from 1995 to 2014, so as to provide the evidence for the strategy revision of the elimination of malaria prevention and control.

Methods: The data of malaria surveillance were collected and analyzed in Shayang County from 1995 to 2014.

Results: During the 20 years, 582 malaria patients (9 imported patients) were reported.