Accumulation of 3-Monochloro-Propanediol Esters in Kidney Tissues of Patients with Human Renal Cell Carcinoma.

Background: 3-Monochloro-propanediol esters (3-MCPDEs), commonly found in refined edible oils and related products, have generated concerns due to their nephrotoxicity and carcinogenicity, yet clinical evidence remains limited.

Objectives: In this study, we aimed to assess, for the first time, the accumulation of 3-MCPDEs in human kidney tissues, focusing on 68 participants, some with and others without renal cell carcinoma (RCC).

Methods: An analytical method for 3-MCPDE determination in kidney tissues underwent partial validation to ensure its suitability for sample analysis.

Evaluation of FeO-MnO@RGO magnetic nanocomposite as an effective persulfate activator and metal adsorbent in aqueous solution.

A reduced graphene oxide (RGO) supported FeO-MnO nanocomposite (FeO-MnO@RGO) was successfully prepared for catalytic degradation of oxytetracycline (20 mg/L) by potassium persulfate (PS) and adsorption removal of mixture of Pb, Cu, and Cd ions (each 0.2 mM) in the synchronous scenario. The removal efficiencies of oxytetracycline, Pb, Cu, and Cd ions were observed as high as 100%, 99.

HIF-2α is indispensable for regulatory T cell function.

Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α are master transcription factors that regulate cellular responses to hypoxia, but the exact function in regulatory T (Treg) cells is controversial. Here, we show that Treg cell development is normal in mice with Foxp3-specific knockout (KO) of HIF-1α or HIF-2α. However, HIF-2α-KO (but not HIF-1α-KO) Treg cells are functionally defective in suppressing effector T cell-induced colitis and inhibiting airway hypersensitivity.

Systematic studies on Yb Bi VO:Tm solid solutions: experiments and DFT calculations on up-conversion photoluminescence properties.

Compound solid solutions have attracted intensive attention due to their adjustable structure, electronic structure, and optical properties. Despite tremendous advances in compound solid solution preparations, combining a rare metal compound and a bismuth compound with the same crystal phase by forming a compound solid solution is still challenging but fascinating. For example, RE Bi VO with a zircon-type structure exhibits tunable band gaps and photoluminescence performance with varying RE compositions.