Publications by authors named "Yu-An Chen"

This study aimed to compare attitudes toward stuttering and cluttering among speech and language therapists (SLTs) and speech and language therapy students in China and how they differ from those in other countries. It also seeks to explore factors that may influence these attitude differences. We utilized online versions of the Public Opinion Survey of Human Attributes-Stuttering (POSHA-S) and Public Opinion Survey of Human Attributes-Cluttering (POSHA-Cl) instruments to conduct surveys of 54 SLTs and 99 SLT students at six Chinese universities offering speech and language therapy programs.

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Structural variants (SVs) have been associated with changes in gene expression, which may contribute to alterations in phenotypes and disease development. However, the precise identification and characterization of SVs remain challenging. While long-read sequencing offers superior accuracy for SV detection, short-read sequencing remains essential due to practical and cost considerations, as well as the need to analyze existing short-read datasets.

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Purpose: This study examined the unmet supportive care needs of lung cancer patients across different cancer stages and treatment phases, as well as the factors associated with these unmet needs.

Patients And Methods: Data from 501 lung cancer patients at a cancer center in central Taiwan were analyzed to assess their unmet supportive care needs across dimensions such as health information, patient care, treatment, nutrition, psychosocial, and economic needs. Associations with sex, age, cancer stage, and treatment phase were investigated.

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High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors. However, the molecular changes that occur as precancerous lesions progress to HGSOC are not well understood. To address this, we integrated high-plex imaging and spatial transcriptomics to analyze human tissue samples at different stages of HGSOC development, including p53 signatures, serous tubal intraepithelial carcinomas (STIC), and invasive HGSOC.

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Most residents of long-term care facilities (LTCFs) are patients with chronic diseases requiring long-term care. Unplanned hospitalization of older and frailer residents from LTCFs reduces their mobility and increases the number of infections, complications, and falls that might lead to severe disability or death. This study aimed to identify the critical risk factors associated with unplanned hospitalization among LTCF residents in Taiwan, providing insights that could inform better care practices in similar settings globally.

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Article Synopsis
  • High-Grade Serous Ovarian Cancer (HGSOC) develops from precursors in the fallopian tubes, yet the molecular changes during this progression are poorly understood.
  • Researchers used advanced imaging and spatial transcriptomics to analyze tissue samples from different stages of HGSOC, revealing critical immune modulating mechanisms and molecular alterations associated with the disease's progression.
  • Findings indicate a shift from immune surveillance to immune suppression in the tumor microenvironment, offering insights into potential biomarkers and therapeutic targets for early detection and intervention in HGSOC.
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  • The tumor microenvironment (TME) significantly impacts the progression of colorectal cancer (CRC), particularly affecting the differences between mismatch repair deficient (dMMR) and proficient (pMMR) tumors.
  • This study utilizes a spatially enhanced version of cBioPortal to analyze the TME and discovers that around 20% of pMMR tumors have T cell infiltration levels similar to dMMR, leading to better survival outcomes.
  • The findings suggest that these T cell-infiltrated pMMR tumors could also benefit from immune checkpoint inhibitor (ICI) therapy, highlighting that factors beyond mutational burden influence immune activity in CRC.
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Background: Older patients with breast cancer are often underrepresented in clinical trials, leading to a lack of evidence-based guidelines for surgical treatment in this cohort. Consequently, synthesizing real-world data is crucial for determining the optimal surgical management of geriatric patients with breast cancer.

Methods: A comprehensive search was conducted of the PubMed, Embase, and Cochrane Library databases.

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SPHK1 (sphingosine kinase type 1) is characterized as a rate-limiting enzyme in sphingolipid metabolism to phosphorylate sphingosine into sphingosine-1-phosphate (S1P) that can bind to S1P receptors (S1PRs) to initiate several signal transductions leading to cell proliferation and survival of normal cell. Many studies have indicated that SPHK1 is involved in several types of cancer development, however, a little is known in bladder cancer. The TCGA database analysis was utilized for analyzing the clinical relevance of SPHK1 in bladder cancer.

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Purpose: This study utilized the Chinese and Japanese translations of the Public Opinion Survey of Human Attributes-Stuttering (POSHA-S) and Cluttering (POSHA-Cl) to compare the differences in (a) attitudes towards stuttering versus cluttering in speech-language pathology (SLP) students in either China or Japan, (b) attitudes of SLP students in China versus Japan towards either stuttering or cluttering, and (c) attitudes of Chinese and Japanese students versus international databases for stuttering and cluttering.

Method: The POSHA-S and POSHA-Cl were both administered to 99 SLP students from six universities in China and 352 SLP students from two universities in Japan.

Results: Attitudes toward stuttering were markedly different for Chinese versus Japanese students.

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Article Synopsis
  • - MXene-based catalysts improve hydrogenation/dehydrogenation kinetics of Mg/MgH but struggle with bond strength and structural stability, prompting the need for better solutions.
  • - The study introduces density control of MXene catalysts and a MnO coating, which allows for significant hydrogen release at various temperatures while maintaining excellent cycle stability.
  • - DFT calculations and XPS analysis reveal that the defects on the MnO@TiC catalyst optimize the Ti-H bond strength, enhancing hydrogen dissociation and diffusion, while the MnO coating protects catalyst stability.
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Background: Insufficient data available for older patients with breast cancer complicates decision-making regarding optimal treatment. A systematic review that uses real-world data is required for assessing the effectiveness and potential adverse effects of various therapies for this age group of patients.

Methods: Databases of PubMed, Embase, and Cochrane Library were searched.

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  • A vegetable nursery in Taichung City, Taiwan, experienced significant spinach seedling production failures in September and October 2022-2023, with about 30% of seedlings showing stunting, yellowing, and root rot.
  • Researchers identified a pathogen linked to the symptoms, with 81% of the plants showing association through genetic analysis of isolates.
  • Phylogenetic analysis indicated that four isolates were identical to a known neotype strain and five isolates were very similar to a reference strain, confirming the presence of specific pathogenic organisms affecting spinach.
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Aim: This study investigated the levels of depression and anxiety in nurses and nursing assistants working in long-term care facilities during the COVID-19 pandemic. We also explored the potential causes of depression and anxiety in nurses and nursing assistants working in long-term care facilities during the pandemic.

Background: The COVID-19 pandemic has had a considerable impact on long-term care facilities.

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We reported that a 31-amino-acid Zfra protein (zinc finger-like protein that regulates apoptosis) blocks neurodegeneration and cancer growth. Zfra binds WW domain-containing oxidoreductase (WWOX) to both - and -termini, which leads to accelerated WWOX degradation. WWOX limits the progression of neurodegeneration such as Alzheimer's disease (AD) by binding tau and tau-hyperphosphorylating enzymes.

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Background: Predictive analytics is gaining popularity as an aid to treatment planning for patients with bone metastases, whose expected survival should be considered. Decreased psoas muscle area (PMA), a morphometric indicator of suboptimal nutritional status, has been associated with mortality in various cancers, but never been integrated into current survival prediction algorithms (SPA) for patients with skeletal metastases. This study investigates whether decreased PMA predicts worse survival in patients with extremity metastases and whether incorporating PMA into three modern SPAs (PATHFx, SORG-NG, and SORG-MLA) improves their performance.

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Background: Task prioritization involves allocating brain resources in a dual-task scenario, but the mechanistic details of how prioritization strategies affect dual-task walking performance for Parkinson's disease (PD) are little understood.

Objective: We investigated the performance benefits and corresponding neural signatures for people with PD during dual-task walking, using gait-prioritization (GP) and manual-prioritization (MP) strategies.

Methods: Participants (N = 34) were asked to hold two inter-locking rings while walking and to prioritize either taking big steps (GP strategy) or separating the two rings (MP strategy).

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Emerging data suggests that HER2 intratumoral heterogeneity (ITH) is associated with therapy resistance, highlighting the need for new strategies to assess HER2 ITH. A promising approach is leveraging multiplexed tissue analysis techniques such as cyclic immunofluorescence (CyCIF), which enable visualization and quantification of 10-60 antigens at single-cell resolution from individual tissue sections. In this study, we qualified a breast cancer-specific antibody panel, including HER2, ER, and PR, for multiplexed tissue imaging.

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The acquisition of blood lactate concentration (BLC) during exercise is beneficial for endurance training, yet a convenient method to measure it remains unavailable. BLC and electrocardiogram (ECG) both exhibit variations with changes in exercise intensity and duration. In this study, we hypothesized that BLC during exercise can be predicted using ECG data.

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Tissue-based sampling and diagnosis are defined as the extraction of information from certain limited spaces and its diagnostic significance of a certain object. Pathologists deal with issues related to tumor heterogeneity since analyzing a single sample does not necessarily capture a representative depiction of cancer, and a tissue biopsy usually only presents a small fraction of the tumor. Many multiplex tissue imaging platforms (MTIs) make the assumption that tissue microarrays (TMAs) containing small core samples of 2-dimensional (2D) tissue sections are a good approximation of bulk tumors although tumors are not 2D.

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Biological plausibility suggests that fluoroquinolones may lead to mitral valve regurgitation or aortic valve regurgitation (MR/AR) through a collagen degradation pathway. However, available real-world studies were limited and yielded inconsistent findings. We estimated the risk of MR/AR associated with fluoroquinolones compared with other antibiotics with similar indications in a population-based cohort study.

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Liver fibrosis is the common pathological pathway of chronic liver diseases and its mechanisms of which have not been fully declared. Macrophages play essential roles in progression of liver fibrosis partially by sensing abnormal mechanical signals. The aim of the study is to investigate the functions of macrophage Piezo1, a mechano-sensitive ion channel, in liver fibrosis.

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Article Synopsis
  • Vibrio α-hemolysins (αHLs) are toxins produced by Vibrio pathogens that cause damage to host cells, playing a key role in bacterial infections.
  • The study focuses on Vibrio campbellii αHL (VcαHL) and shows that its activity is enhanced by calcium ions, which are important for its function and assembly on cell membranes.
  • Advanced techniques like X-ray crystallography and cryo-electron microscopy reveal the structure and changes of VcαHL, highlighting a calcium-binding site crucial for its activation, which could lead to new treatments for Vibrio infections.
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The benefits of branched-chain amino acid (BCAA) administration after hepatic intervention in patients with liver diseases remain unclear. We conducted a systematic review and meta-analysis to evaluate the effects of BCAA on patients undergoing hepatectomy, trans-arterial embolisation and radiofrequency ablation. Relevant randomised controlled trials (RCT) were obtained from PubMed, EMBASE and Cochrane Library databases.

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