Publications by authors named "Yu Yumoto"
Article Synopsis
- In early drug discovery, assessing drug-drug interactions (DDIs) is crucial for understanding how new drug candidates may affect each other's metabolism.
- CYP3A activators can lead to inaccurate assessments of DDIs by specifically impacting the metabolism of midazolam in certain ways.
- The developed CYP cocktail inhibition assay simultaneously evaluates CYP3A activation and inhibition, making it an efficient tool for identifying potential DDIs in the initial phases of drug development.
Aims: Chronic psychological stress aggravates lower urinary tract symptoms. Among others, water avoidance stress is a chronic psychological stressor that plays a causal role in the exacerbation and development of bladder dysfunction in rats. In this report, the effects of KPR-5714, which is a selective transient receptor potential melastatin 8 (TRPM8) antagonist, on bladder overactivity induced by water avoidance stress were examined.
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