Live-attenuated PruΔgra72 strain of Toxoplasma gondii induces strong protective immunity against acute and chronic toxoplasmosis in mice.

Background: Toxoplasma gondii is an intracellular opportunistic pathogenic protozoan that poses serious threats, particularly in immunocompromised individuals. In the absence of a robust prophylactic measure, the mitigation and management of toxoplasmosis present formidable challenges to public health. We recently found that GRA72 plays an important role in parasitophorous vacuole (PV) morphology, growth and virulence of T.

Diagnostic value of circulating microRNAs in thyroid carcinoma: A systematic review and meta-analysis.

Background And Objective: Thyroid cancer (TC) is the most common endocrine system tumour. Several studies had revealed the potential of circulating microRNAs (miRNAs) as novel biomarkers for the diagnosis of TC. The purpose of this meta-analysis is to summarize published studies and evaluate the diagnostic accuracy of circulating miRNAs in TC detection.

miR-26b-5p suppresses proliferation and promotes apoptosis in multiple myeloma cells by targeting JAG1.

Background: Though the levels of diagnosis and treatment of multiple myeloma (MM) have been largely improved recent years, the prognosis of these patients remain unacceptable. It is urgent for us to discover the exact mechanism and determine some new indicators for MM. MiRNAs play a critical role in the occurrence and progression of cancers, including MM.

Abnormal vascular endothelial growth factor protein expression may be correlated with poor prognosis in diffuse large B-cell lymphoma: A meta-analysis.

Objective: We conducted the present meta-analysis with relevant cohort studies to determine whether expression levels of vascular endothelial growth factor. (VEGF) could predict the prognosis of diffuse large B.cell lymphoma.

Borromean-entanglement-driven assembly of porous molecular architectures with anion-modified pore space.

A series of metal-organic frameworks based on a flexible, highly charged Bpybc ligand, namely 1⋅Mn⊃OH(-), 2⋅Mn⊃SO(4)(2-), 3⋅Mn⊃bdc(2-), 4⋅Eu⊃SO(4)(2-) (H(2)BpybcCl(2) = 1,1'-bis(4-carboxybenzyl)-4,4'-bipyridinium dichloride, H(2)bdc = 1,4-benzenedicarboxylic acid) have been obtained by a self-assembly process. Single-crystal X-ray-diffraction analysis revealed that all of these compounds contained the same n-fold 2D→3D Borromean-entangled topology with irregular butterfly-like pore channels that were parallel to the Borromean sheets. These structures were highly tolerant towards various metal ions (from divalent transition metals to trivalent lanthanide ions) and anion species (from small inorganic anions to bulky organic anions), which demonstrated the superstability of these Borromean linkages.