[Cognitive disorders in the middle-aged population and cerebrovascular risk factors].

Aim: To study the frequency of subjective and objective cognitive disorders in the middle-aged population and their associations with main and additional cerebrovascular risk factors.

Material And Methods: The authors examined 169 men and 239 women aged 40-59 years. Medical history study, blood tests, electrocardiography, brachiocephalic and common femoral arteries scan, echocardiography, magnetic resonance imaging of the brain (MRI) were performed.

[Identification of people at the latent stage of Parkinson's disease (the PARKINLAR study): first results and an optimization of the algorithm].

Aim: To work out an optimal algorithm to identify people at the latent stage of neurodegenerative process of «parkinsonian» type in the Russian population.

Material And Methods: Authors launched a two-step study aimed at identifying people at the latent stage of Parkinson's disease (PD) in the Russian population - the PARKINLAR (PARKINsonism, LAtent stage, Russia). As the first step, we formed a group of «primary risk» by the identification in neurologically healthy people of at least one of the following confirmed PD risk factors: a) the substantia nigra hyperechogenicity (ultrasound screening was performed in 193 people); b) mutations in «parkinsonian» genes (genetic screening was performed in 29 relatives of PD patients from families with LRRK2, PARK2 and GBA mutations).