Hub Metabolites Promote the Bioflocculant Production in a Biomass-Degrading Bacterium Pseudomonas boreopolis GO2.

Introduction: The low yield of bioflocculants has been a bottleneck problem that limits their industrial applications. Understanding the metabolic mechanism of bacteria that produce bioflocculants could provide valuable insights and strategies to directly regulate their yield in future.

Methods: To investigate the change of metabolites in the process of bioflocculant production by a biomass-degrading bacterium, Pseudomonas boreopolis GO2, an untargeted metabolome analysis was performed.

PMMA-induced biofilm promotes Schwann cells migration and proliferation mediated by EGF/Tnc/FN1 to improve sciatic nerve defect.

Objective: The purpose of this study is to investigate the role of PMMA-induced biofilm in nerve regeneration compared with silicone-induced biofilm involved in the mechanism.

Methods: PMMA or silicon rods were placed next to the sciatic nerve to induce a biological membrane which was assayed by PCR, Western blot, immunohistochemistry, immunofluorescence and proteomics. A 10 mm sciatic nerve gaps were repaired with the autologous nerve wrapped in an induced biological membrane.

Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure.

Although there have been significant advances in the treatment of heart failure in recent years, chronic heart failure remains a leading cause of cardiovascular disease-related death. Many studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart failure. However, most of the drugs that increase cardiac energy are still in the theoretical or testing stage.

Metal-Perturbed Multiresonance TADF Emitter Enables High-Efficiency and Ultralow Efficiency Roll-Off Nonsensitized OLEDs with Pure Green Gamut.

Multiresonance (MR)-induced thermally activated delayed fluorescence (TADF) emitters based on B- and N-embedded polycyclic aromatics are desirable for ultrahigh-definition organic light-emitting diodes (OLEDs) due to their high photoluminescence quantum yield (PLQY) and narrow bandwidth. But the reverse intersystem crossing (RISC) rates of MR-TADF emitters are usually small, resulting in severe device efficiency roll-off at high brightness. To solve this issue, a sensitizer for the MR-TADF emitter has been required.

Gut-Lung Dysbiosis Accompanied by Diabetes Mellitus Leads to Pulmonary Fibrotic Change through the NF-κB Signaling Pathway.

Growing evidence shows that the lungs are an unavoidable target organ of diabetic complications. However, the pathologic mechanisms of diabetic lung injury are still controversial. This study demonstrated the dysbiosis of the gut and lung microbiome, pulmonary alveolar wall thickening, and fibrotic change in streptozotocin-induced diabetic mice and antibiotic-induced gut dysbiosis mice compared with controls.

One-pot syntheses of irida-polycyclic aromatic hydrocarbons.

Metalla-analogues of polycyclic aromatic hydrocarbons (PAHs) have captivated chemists with their fascinating structures and unique electronic properties. To date, metallabenzene, metallanaphthalene and metallaanthracene have been reported. Metalla-analogues with more complicated fused rings have rarely been reported.

Electronic Properties of Oxidized Cyclometalated Diiridium Complexes: Spin Delocalization Controlled by the Mutual Position of the Iridium Centers.

Four cyclometalated diiridium complexes, with IrCp*Cl (Cp*=η -C Me ) termini bridged by 1,4- and 1,3-bis(p-tolyliminoethyl)benzene (1, 2), or 1,4- and 1,3-bis(2-pyridyl)benzene (3, 4), were prepared and characterized by nuclear magnetic resonance (NMR) spectroscopy and single-crystal X-ray diffraction (complexes 1, 2, and 4). The two iridium centers in complexes 1 and 3 are thus bound at the central benzene ring in the para-position (trans-Ir2), whereas those in complexes 2 and 4 are in the meta-position (cis-Ir2). Cyclic voltammograms of all four complexes show two consecutive one-electron oxidations.

Correction: One-pot syntheses of irida-polycyclic aromatic hydrocarbons.

[This corrects the article DOI: 10.1039/C9SC03914G.].

Excitation Wavelength-Dependent Nearly Pure White Light-Emitting Crystals from a Single Gold(I)-Containing Complex.

A gold(I) complex is reported. Interestingly, crystals of the gold(I) complex exhibit an excellent excitation wavelength-dependent emission effect at room temperature. Notably, a nearly pure white emission with Commission Internationale de L'Eclairage (CIE) 1931 chromaticity coordinates of (0.

CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development.

There is high risk of fetal neurodevelopmental defects in pregestational diabetes mellitus (PGDM). However, the effective mechanism of hyperglycemia-induced neurodevelopmental negative effects, including neural stem cell self-renewal and differentiation, still remains obscure. Neuropoietic cytokines have been shown to play a vital part during nervous system development and in the coordination of neurons and gliocytes.