A Wavy Multiple Tm(III)-Containing Open Wells-Dawson Silicotungstate: Synthesis, Structure, and Catalytic Application.

A Tm(III)-rich silicotungstate Na{Tm(HO)[Tm(HO)(SiWO)]}·35HO () based on the open Wells-Dawson-type [SiWO] building unit was synthesized by the reaction of Na[α-SiWO]·18HO, itaconic acid, and TmCl in a HAc/NaAc buffer solution. Five kinds of Tm(III) ions were found in this compound and further linked the {TmSiW} subunit to form an interesting wavy 1D chain structure, which achieved the introduction of more lanthanide (Ln) ions into the [SiWO] unit for the first time. contains multiple exposed Tm-metal active sites, making it an efficient catalyst for the acetalization of 2-aminobenzamides/2-aminobenzenesulphonamides with aldehydes.

() Is Involved in Host Protection Against Viral Infection.

Baculoviruses, the largest studied insect viruses, are highly pathogenic to host insects. nucleopolyhedrovirus (BmNPV) is the main cause of nuclear polyhedrosis of silkworm, a viral disease that causes significant economic losses to the sericulture industry. The anti-BmNPV mechanism of the silkworm has not yet been characterized.

Low expression of TOX predicts poor prognosis of patients with breast cancer in the real world: A retrospective study.

Background: TOX is a transcription factor that is implicated in the regulation of T cell exhaustion in tumors. TOX has been proven to have prognostic value in some malignant tumors. We aim to analyze the expression of TOX in breast cancer patients, and the association between TOX and prognostic significance in patients with breast cancer.

Engineering an Mn(II)-oxidizing Pseudomonas whole-cell catalyst chassis to efficiently biosynthesize 2,5-furandicarboxylic acid from hydroxymethylfurfural.

2,5-Furandicarboxylic acid (FDCA) is a high-value chemical extensively used in the production of bio-based polymers, but bioconversion of furan derivatives like 5-hydroxymethylfurfural (HMF) into FDCA remains challenging owing to substrate cytotoxicity. Here, we engineered an Mn(II)-oxidizing Pseudomonas sp. MB04B for efficient FDCA biosynthesis from HMF.

Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.

Animals have evolved pH-sensing membrane receptors, such as G-protein-coupled receptor 4 (GPR4), to monitor pH changes related to their physiology and generate adaptive reactions. However, the evolutionary trajectory and structural mechanism of proton sensing by GPR4 remain unresolved. Here, we observed a positive correlation between the optimal pH of GPR4 activity and the blood pH range across different species.

Evaluating the impact of smart city construction on sewage treatment in China from a synergistic perspective.

Urbanization exacerbates the prevalence of urban diseases such as water pollution. Smart city construction (SCC), a prevailing global trend in urban development, has the potential to catalyze the symbiotic development of the urban economy, society, and environment. This study utilized a difference-in-differences (DID) model with panel data from 150 prefecture-level cities in China during the period of 2011-2017 to evaluate the impact of SCC on urban sewage treatment.

Personalized Human Astrocyte-Derived Region-Specific Forebrain Organoids Recapitulate Endogenous Pathological Features of Focal Cortical Dysplasia.

Focal cortical dysplasia (FCD) is a highly heterogeneous neurodevelopmental malformation, the underlying mechanisms of which remain largely elusive. In this study, personalized dorsal and ventral forebrain organoids (DFOs/VFOs) are generated derived from brain astrocytes of patients with FCD type II (FCD II). The pathological features of dysmorphic neurons, balloon cells, and astrogliosis are successfully replicated in patient-derived DFOs, but not in VFOs.

Facile Preparation of Carbon Nanotube-Based Skin-Like Pressure Sensors.

Flexible sensors have garnered significant interest for their potential to monitor human activities and provide valuable feedback for healthcare purposes. Single-walled carbon nanotubes (SWNTs) are promising materials for these applications but suffer from issues of poor purity and solubility. Dispersing SWNTs with conjugated polymers (CPs) enhances solution processability, yet the polymer sidechains can insulate the SWNTs, limiting the sensor's operating voltage.

Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen.

The surge of antimicrobial resistance threatens efficacy of current antibiotics, particularly against Pseudomonas aeruginosa, a highly resistant gram-negative pathogen. The asymmetric outer membrane (OM) of P. aeruginosa combined with its array of efflux pumps provide a barrier to xenobiotic accumulation, thus making antibiotic discovery challenging.

The initial clinical application of standard PCNL combined with visual needle nephroscope in the treatment of complex renal calculi by holmium YAG laser: a retrospective case series study.

This study aims to evaluate the feasibility, safety, and effectiveness of an optimized treatment approach for complex renal calculi, utilizing visual needle nephroscopy in conjunction with standard PCNL and holmium YAG laser. We collected data from 62 patients diagnosed with complex kidney stones who underwent this combined procedure using the visual needle nephroscope (Needle-perc, Youcare Tech, Wuhan, China). The percutaneous nephroscopic working channel was established by visual needle nephroscope, and the primary channel was expanded to 20 F to treat most of the main body of the calculi with a 550 μm holmium laser fiber.

Advancements in the application of semi-solidified feeding in enteral nutrition for critically-ill patients: a comprehensive review.

Enteral nutrition represents the primary modality of nutritional support for critically ill patients. However, challenges such as gastroesophageal reflux, diarrhea, and abdominal distension often manifest during its administration. Enteral nutrition semi-solidified feeding has emerged as a promising alternative, demonstrating notable efficacy.

Pd-Based Multi-Site Catalysts for Selective CO-to-Methanol Conversion.

Developing a multi-site Pd-based electrocatalyst for CO-to-C1 conversion with high performance and selectivity in the hydrogenation pathway for the CO electroreduction reaction is both desirable and challenging. Here, we develop triple-site metallene (PdBiIn), which can achieve an unprecedented Faraday efficiency of 72.6 ± 1% for methanol production.

Conversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acids: bioavailability and dietary regulation.

N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are essential for physiological requirements and disease prevention throughout life but are not adequately consumed worldwide. Dietary supplementation with plant-derived α-linolenic acid (ALA) has the potential to rebalance the fatty acid profile and enhance health benefits but faces challenges such as high β-oxidation consumption, low hepatic conversion efficiency, and high oxidative susceptibility under stress. This review focuses on the metabolic fate and potential regulatory targets of ALA-containing lipids , specifically the pathway from the gastrointestinal tract to the lymph, blood circulation, and liver.

An ultrasonic degraded polysaccharide extracted from Pueraria lobata ameliorate ischemic brain injury in mice by regulating the gut microbiota and LPS-TLR4 pathway.

Ischemia brain injury is closely associated with the gut microbiota. Polysaccharides, as a typical prebiotic, have been extensively employed in stroke treatment. In our previous study, Pueraria lobata polysaccharide (PLP-3) with antioxidant activity was prepared via water extraction and alcohol precipitation combined with ultrasonic degradation.

Selfing Shapes Fixation of a Mutant Allele Under Flux Equilibrium.

Sexual reproduction with alternative generations in a life cycle is an important feature in eukaryotic evolution. Partial selfing can regulate the efficacy of purging deleterious alleles in the gametophyte phase and the masking effect in heterozygotes in the sporophyte phase. Here, we develop a new theory to analyze how selfing shapes fixation of a mutant allele that is expressed in the gametophyte or the sporophyte phase only or in two phases.

Early onset pancreatic cancer: A review.

Early-onset pancreatic cancer (EOPC) is usually defined as patients with pancreatic cancer before the age of 50 years, which is relatively rare. However, the research on EOPC is somewhat obscure, and the specific clinical and molecular characteristics of this condition are debated. In this review, we discussed the differences between EOPC and late-onset pancreatic cancer (LOPC) or average-onset pancreatic cancer (AOPC) with a focus on clinical and molecular characteristics, survival outcomes and treatment to promote the diagnosis and treatment of EOPC.

Synergistic Contribution of the Strain and Magnetic Field in Ferromagnetic NiMnIn Heusler Alloy Films for the Hydrogen Evolution Reaction.

The external field-assisted hydrogen evolution reaction (HER), beyond modifying electrocatalysts themselves, has garnered significant research attention. However, achieving synergy between multiple fields to enhance the HER performance remains challenging and is not well-explored. Here, NiMnIn Heusler alloy thin films are fabricated using pulsed laser deposition on flexional Cu substrates.

Deficiency of the histone H3K36 methyltransferase SETD2 inhibits the proliferation and migration of hepatocellular carcinoma cells.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. SETD2, the only known methyltransferase catalyzes the trimethylation of histone H3 lysine 36 (H3K36), has been reported to be associated with several cancers. However, the function of SETD2 in HCC is unclear.

Laboratory Evaluation of the Xpert Xpress Flu/RSV Test in Hubei, China.

Background: Early confirmation of infections with influenza virus and/or respiratory syncytial virus (RSV) is beneficial for prompt treatment and outbreak management. This study aimed to assess the Cepheid Xpert Xpress Flu/ RSV assay in Central China, using Sanger sequencing as the reference method.

Methods: Nasopharyngeal swab (NP) samples from pediatric and adult patients with influenza-like illnesses were collected by the Hubei Province Disease Control and Prevention Center.