Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.

Redox imbalance, including excessive production of reactive oxygen species (ROS) caused by mitochondrial dysfunction and insufficient endogenous antioxidant capacity, is the primary cause of myocardial ischemia‒reperfusion (I/R) injury. In the exploration of reducing myocardial I/R injury, it is found that protecting myocardial mitochondrial function after reperfusion not only reduces ROS bursts but also inhibits cell apoptosis triggered by the release of cytochrome c. Additionally, nuclear factor erythroid 2-related factor 2 (Nrf2) is considered a potential therapeutic target for treating myocardial I/R injury by enhancing the cellular antioxidant capacity through the induction of endogenous antioxidant enzymes.

Inhibitory effect of bioactive compounds from quinoa of different colors on the in vitro digestibility of starch.

This study aimed to compare the bioactive compounds presented in quinoa of various colors, and investigated their inhibitory effect on α-glucosidase activity and the in vitro digestibility of starch. The primary bioactive compounds identified in quinoa included betaine and polyphenols (kaempferol, quercetin, rutin, etc.), with their contents increased as the color of quinoa darkened.

Mangrove flourishing/deterioration under the control of the Indian Summer Monsoon over the past ∼3,195 years in Phang Nga Province, Thailand.

Mangrove wetlands are strategic locations for mitigating climate changes. In order to address the harm of rapid climate change to mangrove ecosystems, it is necessary to scientifically predict the fate of mangrove ecosystems, which can be achieved by reconstructing the development history of mangrove forests. This study analyzes the contribution of mangrove-derived organic matter (CMOM) from sediment core F in Phang Nga Province, Thailand by using the endmember mixing model based on stable organic carbon isotopes (δC) and C/N (molar) ratio.

Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis.

Background: Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20-30% of CRC patients already present with liver metastases. Colorectal liver metastasis (CRLM) is a major cause of mortality among CRC patients.

Xenia Effect on Nutritional and Flavor Components of 'Jingbaili' Pear.

The 'Jingbaili' pear is a national geographical indication product of China, featuring an oblate shape and being rich in nutrients. But the quality of the 'Jingbaili' pear is unstable. Xenia can cause changes in the quality of pears, but the effect of xenia on the 'Jingbaili' pear is unknown, and its mechanism is still unclear.

Contributions to the () Group in China: Taxonomy, Species Diversity, and Molecular Phylogeny.

is the largest genus in the family , with approximately 1000 species worldwide. Basic data on the species diversity, geographic distribution, and the infrageneric framework of are still incomplete because of the intricate nature of this genus, which includes numerous unrecognized taxa that exist around the world. A multigene phylogeny of the group, initially designated as the " subgroup", was conducted using the ITS-28S- nucleotide datasets.

eEF2K alleviates doxorubicin-induced cardiotoxicity by inhibiting GSK3β and improving autophagy dysfunction.

Doxorubicin-induced cardiotoxicity (DIC) poses a threat to the health and prognosis of cancer patients. It is important to find a safe and effective method for the prevention and treatment of DIC. eEF2K, which is a highly conserved α-kinase, is thought to be a therapeutic target for several human diseases.

Long-Term Propolis Intake-Induced Liver Lipid Remodeling in Mice: Effects on Phospholipid-to-Glycerolipid Metabolism and Free Fatty Acid-Mediated Thermogenesis.

Research on the patterns and mechanisms of liver lipid remodeling regulated by propolis is limited. In the present study, the nine-month experimental duration has shed light on the positive influences of propolis on lipid metabolism and thermogenesis capacity in the livers of mice. Eight major compounds in propolis were characterized using UPLC-QTOF-MS technology.

Integrated analysis of single-cell and bulk RNA-sequencing identifies a metastasis-related gene signature for predicting prognosis in lung adenocarcinoma.

Background: Metastasis has been documented as an independent and significant prognostic feature of lung adenocarcinoma (LUAD) patients. However, the underlying genetic and molecular mechanisms responsible for LUAD metastasis and their prognostic significance are not exactly defined.

Methods: The single-cell transcriptomic profiles of primary and metastatic LUAD samples were integrated as a whole dataset.

Zn-Doped Hollow Cubic MnO as a High-Performance Cathode Material for Zn Ion Batteries.

Manganese-based compounds have the characteristics of high theoretical capacity, low cost and stable performance, thus become a research hotspot for cathode materials of zinc-ion batteries (ZIBs). However, in the process of charging and discharging, it is accompanied by problems such as structural collapse and low conductivity, which resulted in severe capacity degration during cycles. In this paper, a kind of Zn doped MnO hollow cube cathode material (Zn-MnO) was prepared by self-sacrificing template method.

Numerical Analysis in Double-Sided Polishing: Mechanism Exploration of Edge Roll-Off.

Understanding the mechanism of stress concentration effects on the surface of semiconductor substrate materials-silicon wafers-in Double-Sided Polishing (DSP) is particularly important for improving polishing quality. In this study, a two-dimensional finite element model is established to study the effect of contact state and stress concentration during polishing on edge roll-off (ERO) and polishing rate uniformity. The variation in this contact state is influenced by changes in wafer thickness and the gap between it and the carrier.

His bundle pacing combined with atrioventricular node ablation for atrial fibrillation: a systematic review and meta-analysis.

Introduction And Objective: His bundle pacing (HBP) could replace failed biventricular pacing (BVP) in guidelines (IIa Indication), but the high capture thresholds and backup lead pacing requirements limit its development. We assessed the efficacy and safety of HBP combined with atrioventricular node ablation (AVNA) for atrial fibrillation (AF) and compared with BVP and left bundle branch pacing (LBBP).

Methods: We reviewed PubMed, Embase, Web of Science, and Cochrane Library databases on left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) score, QRS duration (QRSd), and pacing threshold.

IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption.

The airway surface liquid (ASL) plays a crucial role in lung defense mechanisms, and its composition and volume are regulated by the airway epithelium. The cystic fibrosis transmembrane conductance regulator (CFTR) is abundantly expressed in a rare airway epithelial cell type called an ionocyte. Recently, we demonstrated that ionocytes can increase liquid absorption through apical CFTR and basolateral barttin/chloride channels, while airway secretory cells mediate liquid secretion through apical CFTR channels and basolateral NKCC1 transporters.

Polluted soil-plant interaction analysis and soil classification based on laser-induced breakdown spectroscopy and machine learning.

A new method is introduced for the swift and precise detection of soil pollution and its effects on crops. Soil quality is essential for human well-being, with heavy metal pollution presenting considerable risks to both the ecological environment and human health. In crops, heavy metal contamination primarily occurs through mediums such as soil and water sources.

FOXM1 affects oxidative stress, mitochondrial function, and the DNA damage response by regulating p21 in aging oocytes.

Fertilization capacity and embryo survival rate are decreased in postovulatory aging oocytes, which results in a reduced reproductive rate in female animals. However, the key regulatory genes and related regulatory mechanisms involved in the process of postovulatory aging in oocytes remain unclear. In this study, RNA-Seq revealed that 3237 genes were differentially expressed in porcine oocytes between the MII and aging stages (MII + 24 h).

[LSTM-XGBoost Based RR Intervals Time Series Prediction Method in Hypertensive Patients].

Objective: The prediction of RR intervals in hypertensive patients can help clinicians to analyze and warn patients' heart condition.

Methods: Using 8 patients' data as samples, the RR intervals of patients were predicted by long short-term memory network (LSTM) and gradient lift tree (XGBoost), and the prediction results of the two models were combined by the inverse variance method to overcome the disadvantage of single model prediction.

Results: Compared with the single model, the proposed combined model had a different degree of improvement in the prediction of RR intervals in 8 patients.

Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation.

How the dorsal-ventral axis of the vertebrate jaw, particularly the position of tooth initiation site, is established remains a critical and unresolved question. Tooth development starts with the formation of the dental lamina, a localized thickened strip within the maxillary and mandibular epithelium. To identify transcriptional regulatory networks (TRN) controlling the specification of dental lamina from the naïve mandibular epithelium, we utilized Laser Microdissection coupled low-input RNA-seq (LMD-RNA-seq) to profile gene expression of different domains of the mandibular epithelium along the dorsal-ventral axis.

Laser-Printed All-Carbon Responsive Material and Soft Robot.

Responsive materials and actuators are the basis for the development of various leading-edge technologies but have so far mostly been designed based on polymers, incurring key limitations related to sensitivity and environmental tolerance. This work reports a new responsive material, laser-printed carbon film (LPCF), produced via direct laser transformation of a liquid organic precursor and consists of graphitic and amorphous carbons. The high activity of amorphous carbon combined with the dual-gradient structure enables the LPCF to have a actuation speed of 9400° s in response to the stimulus of organic vapor.

New insights into the evolution and local adaptation of the genus in east Asia.

Chestnut plants () are important nut fruit trees worldwide. However, little is known regarding the genetic relationship and evolutionary history of different species within the genus. How modern chestnut plants have developed local adaptation to various climates remains a mystery.

Rapid in situ identification of honey authenticity based on RP-Nano-ESI-MS using online desalting.

High-content sugar in honey frequently results in severe matrix effects and requires complex pretreatment prior to analysis, posing significant challenges for the rapid analysis of honey. In this study, the reversal polarity nano-electrospray ionization mass spectrometry (RP-Nano-ESI-MS) analysis was developed for the direct evaluation of honey samples. The results indicated that RP-Nano-ESI-MS significantly mitigated the matrix effects induced by high-content sugar through the implementation of online desalting.