Publications by authors named "Yu Wei"
Background: Atherosclerosis (AS) is a major cause of cardiovascular diseases and neutrophil extracellular traps (NETs) may be actively involved in the development of atherosclerosis. Identifying key biomarkers in this process is essential for developing targeted treatments for AS.
Methods: We performed bioinformatics analysis using a NETosis-related gene (NRGs) set and three AS datasets (GSE100927, GSE21545, and GSE159677).
Article Synopsis
- Recent studies highlight the advantages of using intravascular imaging (IVI) for percutaneous coronary intervention (PCI) compared to traditional angiography, but the relevance of angiography-based physiological assessments during this procedure is not fully understood.
- The FLAVOUR trial analyzed the impact of angiography-based physiological evaluations, specifically the quantitative flow ratio (μQFR), on treatment decisions for patients undergoing IVI-guided PCI.
- Results indicated significant reclassification of treatment approaches based on μQFR, with the REFERENCE group experiencing a higher risk of major adverse cardiovascular events, while DEFER and PERFORM groups showed similar outcomes and quality of life after 2 years.*
Article Synopsis
- Coronary artery disease (CAD) is a major global health issue, and combining coronary X-ray angiography (XA) with optical coherence tomography (OCT) can enhance diagnosis and treatment by providing detailed images of coronary anatomy and plaque structure.
- The new framework, AutoFOX, employs a deep learning model called TransCAN to accurately align 3D vascular images, achieving impressive alignment precision, especially at critical anatomical points.
- AutoFOX also includes innovative methods for reconstructing side branches and utilizes a diverse dataset for validation, demonstrating strong accuracy and reliability in assessing bifurcation lesions, which is essential for improving CAD management and procedures.
Polymer-based thermally conductive composites are widely used in microelectronics for heat dissipation and packaging, for which the filler arrangement and the filler/matrix interfacial thermal resistance (ITR) are key factors limiting superior thermal conduction realization. This work reveals the effects of filler modification and orientation on thermal duction in the boron nitride (BN)/hydroxyethyl cellulose (HEC) through multiscale simulation approaches. Nonequilibrium molecular dynamics (NEMD) identifies that the thermal conductivity of the BN molecule is not size-dependent and proves that thermal resistance is dramatically reduced after hydroxylation modification (BN).
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- - The study aimed to explore how three atherosclerosis indexes relate to the risk of stroke in individuals aged 65 and older from China between 2011 and 2015.
- - Using multivariate logistic regression, researchers found that the highest quartiles of the atherogenic index of plasma (AIP), Castelli risk index I (CRI-I), and Castelli risk index II (CRI-II) indicated increased odds of stroke compared to the lowest quartiles.
- - The findings suggest that higher levels of these atherosclerosis indexes significantly correlate with an increased risk of stroke, highlighting their potential as predictive factors in elderly populations.
Article Synopsis
- A mixed integer programming model was developed to prioritize fuel treatments in a fuel break network, aiming to reduce wildfire size and protect Wildland Urban Interface areas.
- The model utilizes simulated wildfire data from a large landscape to inform effective fuel treatment decisions while maintaining computational efficiency and customization options.
- Testing in Southern California showed that the optimization model outperforms traditional rule-based approaches, providing better solutions for fuel break management and planning within a reasonable timeframe.
Article Synopsis
- The study focuses on understanding the mechanisms behind the cholangiocellular phenotype (CCA) in hepatocellular carcinoma (HCC), particularly the roles of specific cell types in tumor progression.
- Utilizing single-cell RNA sequencing, researchers identified a unique subset of senescent endothelial cells (CD34CLDN5 ECs) that promote tumor growth by secreting IGF2, which attracts mesenchymal stem cells (MSCs) to the tumor microenvironment.
- The interaction between these senescent ECs and MSCs was shown to enhance cancer malignancy, revealing potential targets for therapeutic intervention in HCC.
The integration of photocatalytic and photothermal materials with oil-water separation membranes marks a significant advancement in sustainable separation technologies. These hybrid membranes exhibit exceptional functionalities, including resistance to oil fouling, self-cleaning, antibacterial properties, and reduced oil viscosity. Based on their reaction mechanisms, current photocatalytic and photothermal membranes are categorized into four types, i.
View Article and Find Full Text PDFPostoperative cognitive dysfunction (POCD) is a prevalent neurocognitive complication of anesthesia and surgery. Metformin, a widely used antidiabetic drug, has neuroprotective properties and improves cognitive impairment and memory deficits. However, the mechanisms underlying its action in improving cognitive dysfunction after anesthesia and surgery remain unclear.
View Article and Find Full Text PDFBDE-209 exposure induced male reproductive toxicity with sperm quality decline. However, the role of autophagy in this was unclear. The purpose was to evaluate the protective effect and its potential mechanism of trehalose (Tre, autophagy inducer) on reproductive damage during spermiogenesis induced by BDE-209.
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- Researchers explored how combining DNA vaccination with a potent HBV neutralizing antibody might improve treatment for chronic HBV infections, which are hard to manage due to weak immune responses.
- In a study with mice, treatment with the antibody and a DNA vaccine led to the development of specific immune cells in the liver, enhancing immune recruitment but also indicating T cells became dysfunctional over time.
- While this combination therapy did not fully cure the infection, it showed promise by improving the immune response and providing insights into how the liver tolerates HBV.
Article Synopsis
- - Scientists identified specific proteins and molecules in the central nervous system (CNS) that can be targeted to create engineered cells for therapy.
- - They developed synthetic Notch receptors to program T cells to release certain treatments only in the brain, effectively clearing brain tumors without affecting cells in other areas.
- - The research also found that T cells delivering interleukin-10, an immune-suppressing cytokine, helped reduce symptoms in a mouse model of neuroinflammation, showing potential for targeted treatment strategies.
Article Synopsis
- Dietary choices significantly influence the occurrence of cardiovascular disease (CVD), but finding the best dietary pattern to reduce risk in high-risk individuals is difficult.
- A study evaluated food consumption frequencies among 28,979 high-risk subjects, linking increased egg and seafood consumption to a lower risk of major CVD events, such as coronary heart disease and stroke.
- A nomogram was developed to help predict 3- and 5-year CVD incidence based on various dietary and non-dietary risk factors, offering practical dietary guidance for preventing CVD in at-risk populations.*
Triple oxygen isotope composition (Δ'O) of sulfate carries information on the sulfur cycle as well as signatures of atmospheric O, O, and surface water of the geological past. However, existing analytical techniques can only achieve a partial oxygen yield during the conversion from sulfate to the analyte O, which results in isotope fractionation and impedes the Δ'O comparison with other oxygen-bearing compounds (e.g.
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- Nanomotors show promise for delivering drugs deep into cancer stem cells within tumors, enhancing treatment effectiveness.
- This study introduces a specialized pH-responsive Janus nanomotor designed to respond to tumor microenvironment stimuli, allowing for improved drug distribution.
- The unique propulsion methods of these nanomotors, driven by chemical reactions and external light, ensure consistent movement and targeting capabilities for more efficient cancer therapy.
[Construction and biological activity of metallothionein fused with ELP].
Sheng Wu Gong Cheng Xue Bao
November 2024
Article Synopsis
Article Synopsis
- - Chronic obstructive pulmonary disease (COPD)-associated expiratory central airway collapse (ECAC) is a benign but often overlooked condition that leads to airway obstruction, and its diagnosis and treatment are complicated due to unclear mechanisms and atypical symptoms.
- - Bronchoscopy is the best method for diagnosing ECAC, while noninvasive ventilation and temporary airway stents are common treatment options, though their long-term use and effectiveness still require further investigation.
- - There is a growing need for research, including randomized controlled trials, cost-effectiveness analyses, and guidelines to improve understanding and management of COPD-associated ECAC in patients.
Multiresponsive Ionogel with Switchable Adhesion Triggered by Phase Separation.
ACS Appl Mater Interfaces
December 2024
The rapid development of wearable devices and soft robotics has an urgent demand for polymer conductors with a switchable adhesion property. Herein, we report a supramolecular ionogel (SIG) that can reversibly switch between adhesion and debonding to various substrates. The on/off switchable adhesion of SIG is attributed to phase separation induced by the aggregation of polymer chains and the formation of a lubricating layer, which impairs the contact between polymer chains and substrates, thus weakening interfacial interaction.
View Article and Find Full Text PDFBackground: Thyroid hormone resistance syndrome (RTH) is a rare hereditary endocrine disease that can manifest as hyperthyroidism, hypothyroidism, or remain asymptomatic. It can easily be confused with other types of thyroid diseases. The diagnosis of the disease depends on genetic testing.
View Article and Find Full Text PDFIndigenous rangers play a critical role in achieving global biodiversity goals by facilitating effective conservation and community development. However, there is limited knowledge about rangers' livelihoods and responses to conservation policies. This study examined indigenous rangers' perceptions of livelihood impacts and attitudes toward national park management in Three-River-Source National Park (TRSNP).
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- Pancreatic cancer's resistance to T cell immunity limits the effectiveness of immunotherapy, but a study found that the protein MCRS1 can improve this sensitivity in mouse models.
- MCRS1 works by interacting with the YY1 transcription factor, enhancing the expression of MHC-I genes, which are crucial for T cell recognition of cancer cells.
- High levels of MCRS1 are linked to better patient outcomes in pancreatic cancer and indicate a positive response to α-PD-1 therapy, suggesting MCRS1 could be a target to improve treatment for solid tumors.