[Prospects of combined anterior prosthetic hernia repair in treatment of large and giant ventral hernias].

Aim: To evaluate clinical efficacy of combined anterior prosthetic hernia repair in treatment of large and giant ventral hernias.

Material And Methods: Patients with large and giant hernias have been analyzed. In the main group (n=675) combined methods of hernia gates repair were applied, in control group (n=257) - stretching repair including prosthesis deployment.

[Preclinical tests of additive materials for personified endoprostheses of hand joints].

Aim: To evaluate the biocompatibility of additive materials for personified endoprostheses of hand joints in vivo.

Material And Methods: We tested a material based on titanium that was implanted into muscles and bone tissue in experiment on rabbits. Follow-up was 30 and 90 days.

Sources of Reactive Oxygen and Nitrogen Species in Tissue Microenvironment of Hernioplasty Materials.

Titanium and polypropylene mesh endoprostheses were implanted into the rat abdominal cavity and the populations of cells migrating to their surface were analyzed. On both materials, the cells were presented mainly by macrophages that proliferated, activated, and fused to form multinuclear cells. Contact with the foreign surface triggered superoxide anion generation and myeloperoxidase synthesis by macrophages (these processes were more intense on polypropylene implants than on titanium ones) and stimulated production of nitric oxide by macrophage.