Young and old animals use various strategies of metabolic adaptation to Cu-induced liver fibrosis.

The role of the prooxidant-antioxidant and immune systems in formation of age-related adaptive responses to chronic effects of toxic substances (copper ions) was studied. In this purpose in young and old animals by multiple sequential administration of copper sulfate was induced liver fibrosis. Using this model the characteristics of prooxidant-antioxidant and immune systems, and physiological characteristics of were assessed.

Thermogenesis and longevity in mammals. Thyroxin model of accelerated aging.

Development of experimental models of life span regulation is an important goal of modern gerontology. We proposed a thyroxin model of accelerated aging. Male Wistar rats at the age of 17 months received thyroxin in drinking water at a concentration of 6 mg/L for 2 months as a model of induced hyperthyroidism (IH).

Prooxidant-antioxidant balance in the prostate and blood of rats with sulpyride[corrected]-induced prostatic hyperplasia corrected with prostatilen.

We studied the effects of 30-day injections of sulpyride and treatment with Prostatilen on the development of prostatic hyperplasia and LPO in rats. Sulpyride induced proliferation of lateral lobes, increased the content of lipid hydroperoxides and glutathione peroxidase activity in the gland; in the blood this preparation increased lipid hydroperoxide concentration and decreased glutathione peroxidase and total antioxidant activity. Prostatilen prevented the development of hyperplasia and normalized the prooxidant-antioxidant balance in tissues, except total antioxidant activity of the blood.