[Clinical manifestations of orbital lesion in granulomatosis with polyangiitis].

Unlabelled: One of the most common and potentially threatening manifestations of granulomatosis with polyangiitis (GPA) is orbital lesion.

Purpose: To study the clinical course and prognosis of orbital lesions of various localization in GPA patients. Material and me-thods.

[The frequency of ophthalmologic manifestations of granulomatosis with polyangiitis (Wegener's) and their relationship to systemic diseases].

Aim: To estimate the frequency of lesions in the organ of vision in granulomatosis with polyangiitis (GPA) (Wegener's) and to determine their relationship to systemic diseases.

Subjects And Methods: The retrospective study enrolled 218 patients followed up at the E.M.

[Combination therapy of refractory localized granulomatosis with polyangiitis and orbital involvement].

Granulomatous orbital cellulitis is one of the most common ocular manifestations of granulomatosis with polyangiitis (Wegener's). The process is often refractory to conventional immunosuppressive therapy and requires a more radical treatment approach. However, surgical experience with this type of patients is limited.

[Refractory form of orbital granulomatosis with polyangiitis: A clinical and morphological study].

Orbital granulomatosis with polyangiitis (Wegener's granulomatosis, GPA), which is characterized by granulomatous inflammation with small-vessel vasculitis, can develop in local and generalized forms of the disease. The introduction of current immunosuppressive therapy regimens has improved the prognosis of the disease; however, there are immunosuppressive treatment-refractory forms of GPA, the morphology of which has been inadequately investigated. The paper describes a clinical case of refractory GPA involving the orbit, as evidenced by histological and immunohistochemical examinations.

[Ophthalmologic manifestation of granulomatosis with polyangiitis (Wegener's granulomatosis)].

Granulomatosis with polyangiitis (GPA), formerly earlier known as Wegener's granulomatosis, is primary system necrotizing vasculitis of small and medium-sized vessels, which is characterized by the formation of foci of granulomatous inflammation. One of the target organs in GPA is the organ of vision. Its affection may not only reduce quality of life, but also may lead to the severest complications even to fatal outcome.