Publications by authors named "Yu Tao Yan"
[Immunological characteristics induced in mice by nucleic acid vaccine harboring the gene encoding GAPDH in Schistosoma japonicum].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
October 2005
Objective: To study the immunological characteristics induced in C57BL/6 mice by nucleic acid vaccine harboring the gene encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Schistosoma japonicum.
Methods: The gene encoding GAPDH of S. japonicum from screening of cDNA library was amplified using universal primer T3 promoter and T7 promoter, the PCR product was cloned into the T-A vector pT-Adv.
Article Synopsis
- The EGF receptor (EGF-R) is crucial for cellular development and differentiation, with similar proteins found in many organisms.
- Research focused on SER, an EGF-R-like molecule in the helminth parasite Schistosoma mansoni, revealing its ability to activate the Ras/ERK pathway in response to human EGF.
- Experimental data showed that human EGF triggers significant cellular processes in S. mansoni, including protein synthesis and phosphorylation, suggesting that host EGF may influence the parasite's growth and development.