Publications by authors named "Yu Tai Lo"

Introduction: With advances in medicine and the resultant increased ageing population, dementia, including Alzheimer's disease, has become a leading cause of death in individuals aged over 65 years in nursing homes. The unpredictable trajectory of the disease, marked by cognitive and functional decline, necessitates intensive healthcare and poses challenges to end-of-life (EoL) care decisions, particularly because majority of the affected individuals become unable to make their own decisions. This highlights the importance of advance care planning (ACP) programmes that enable individuals with dementia to define and communicate their EoL care decisions in advance.

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Caring for patients with dementia at risk of getting lost is challenging for community healthcare providers. Through semi-structured interviews with 25 participants, we examined the challenges faced by these providers and the strategies they employed. We identified the following themes of challenging parts: (a) the disturbance caused by behavioral and psychological symptoms in dementia; (b) difficulty in helping older family caregivers to keep the patient from going out; (c) difficulty in changing the attitudes of the family members; families' unawareness of the risk of getting lost.

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  • Medication non-adherence is common among older adults with non-communicable diseases (NCDs), leading to increased hospitalizations and mortality.
  • A study involving 1,268 older adults in Taiwan found that those with lower overall intrinsic capacity (IC) levels were more likely to not stick to their medication regimens.
  • Specific factors such as cognitive impairment, hearing loss, and depressive symptoms significantly increased the chances of non-adherence, suggesting that programs to boost medication adherence should focus on improving IC.
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  • The FIND-NEEDS screening tool was developed to quickly identify common geriatric conditions, aiming to simplify the comprehensive geriatric assessment (CGA) process, which is typically time-consuming and labor-intensive.
  • In a study with 114 participants aged 65 and older, FIND-NEEDS was evaluated against CGA for validity, revealing strong correlations and excellent sensitivity and specificity.
  • The results suggest that FIND-NEEDS is a reliable and efficient tool for assessing health needs in older adults, potentially streamlining healthcare evaluations in geriatric settings.
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Dengue is one of the most common epidemic infections around the world. Dengue infections in older adults are related to an atypical presentation and a high mortality. Frailty is associated with poor recovery from hospitalization due to infection.

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Advance care planning (ACP) has the potential to improve the outcomes of end-of-life care for residents in nursing homes. The aim of this study was to determine whether an ACP program was beneficial for nursing home residents by assessing end-of-life indicators. An experimental study with a retrospective chart review was conducted.

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Purpose: To develop and internally validate a novel prediction score to predict the occurrence of arterial-esophageal fistula (AEF) in esophageal cancer bleeding.

Methods: This retrospective cohort study enrolled patients with esophageal cancer bleeding in the emergency department. The primary outcome was the diagnosis of AEF.

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Background: Population aging has increased the prevalence of multimorbidity, jeopardizing the sustainability and efficiency of healthcare systems. This study aimed to evaluate the effects of an integrated ambulatory care program (IACP) on healthcare utilization and costs among older patients with multimorbidity while accounting for the confounding effects of frailty.

Methods: A retrospective cohort study using propensity matching including patients aged 65 or older with two or more chronic conditions attending the outpatient clinic at our hospital between June 1 and December 31, 2019, was conducted.

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  • * Researchers found 45 unique metabolites in the hair of 6-month-old 5xFAD mice, highlighting key metabolic pathways like arachidonic acid and sphingolipid metabolism, which could be important in the early stages of AD.
  • * The analysis identified a promising combination of l-valine and arachidonic acid as potential biomarkers that could effectively distinguish patients with AD from those without, showcasing hair metabolomics as a valuable tool for disease detection and monitoring.
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Background And Objectives: Multimorbidity increases risks, such as polypharmacy, inappropriate prescription, and functional decline. It also increases medical care utilization by older adults, placing a burden on health care systems. This study evaluated the effectiveness of an integrated ambulatory care program for health care and medication use in patients with multimorbidity and polypharmacy.

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Background: The benefit of inpatient comprehensive geriatric assessment on patient survival and function has been demonstrated among frail older patients. However, the influence of outpatient geriatric evaluation and management (GEM) on clinical outcomes remains debated. This study aimed to update the research evidence detailing the effect of outpatient GEM on survival and nursing-home admission through a comparison with conventional care.

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Introduction: We compared the ranking of Alzheimer's disease and related dementia (ADRD) among the leading causes of death (LCODs) between those according to the National Center for Health Statistics (NCHS) and the World Health Organization (WHO) lists by sex.

Method: The number of deaths in each LCOD category was obtained from CDC WONDER.

Results: According to the WHO list, ADRD was the second LCOD from 2005 to 2013, the first from 2014 to 2020, and the third in 2021, respectively, for women and was the second in 2018 and 2019, the third in 2020, and the fourth in 2021, respectively, for men.

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Background: Fear of falling (FOF) is a common and major health concern in older adults. The consequences of FOF include reduced physical performance, social activity, and health-related quality of life. Ramsay Hunt syndrome (RHS) is a herpes zoster-related facial nerve dysfunction accompanied by an erythematous vesicular rash on the ear or mouth that may complicate ipsilateral facial paralysis and otalgia, vertigo, tinnitus, hearing loss, and meningoencephalitis.

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Background: Treatment protocols for two-stage revision arthroplasty with diabetes mellitus (DM) have not yet been established. The control of glycated hemoglobin (HbA1c) in two-stage revision arthroplasty is still debated. This study aimed to clarify the importance of preoperative HbA1c levels before each stage of revision arthroplasty and to analyze the risk factors for reinfection.

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Background: Physical resilience is known to minimize the adverse outcomes of health stressors for older people. However, validated instruments that assess physical resilience in older adults are rare. Therefore, we aimed to validate the Physical Resilience Instrument for Older Adults (PRIFOR) to fill the literature gap.

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Article Synopsis
  • Early unplanned hospital readmissions can lead to serious patient harm, increased costs, and harm a hospital's reputation, making it essential to identify at-risk patients for targeted interventions.
  • A study analyzed 37,091 adult patients from a university hospital, using four machine learning algorithms to predict the likelihood of 14-day unplanned readmissions, with Catboost demonstrating the best performance overall.
  • After refining the model with 21 key features, the final predictions showed improved accuracy, suggesting that machine learning could effectively help reduce unplanned hospital readmissions.
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Background/purpose: Early unplanned hospital readmissions are burdensome health care events and indicate low care quality. Identifying at-risk patients enables timely intervention. This study identified predictors for 14-day unplanned readmission.

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Objectives: To report the prevalence of Do-Not-Resuscitate (DNR) directives and to explore the factors associated with the presence of DNR directives among nursing home residents in Taiwan.

Design: A cross-sectional, correlation study.

Setting: Seven nursing homes in southern Taiwan.

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