Publications by authors named "Yu Su"

Calcineurin (CN), a serine/threonine protein phosphatase regulated by Ca and calmodulin, plays a crucial role in the immune response of bivalves. In this study, we examined the effects of gene silencing of the CN subunit (HcCnAα) in Hyriopsis cumingii on the expression of genes associated with the NF-κB signaling pathway, as well as the phosphorylation of the inhibitor of NF-κB (IκB), through RNA interference (RNAi), quantitative PCR (qPCR), and Western blot (WB) analyses. The IκB kinase (HcIKK) and B-cell CLL/lymphoma 10 (HcBcl10) genes of H.

View Article and Find Full Text PDF

Background: Immune-mediated liver injury caused by immune checkpoint inhibitors (ILICI) and autoimmune hepatitis (AIH) are both related to the distorted immune system. However, ILICI differs from AIH in several distinct ways. We aimed to study the differences between ILICI and AIH.

View Article and Find Full Text PDF

The trigeminal ganglion (TG) comprises primary sensory neurons responsible for orofacial sensations, subsequently projecting to the trigeminal nuclei in the brainstem. However, the circuit basis of nasal mechanosensation is not well characterized. Here we elucidate the anatomical organization of both peripheral and central projections of the TG.

View Article and Find Full Text PDF
Article Synopsis
  • - Plant roots interact with soil and face challenges like water balance and nutrient uptake, utilizing apoplastic diffusion barriers to regulate solute flow.
  • - This Review covers recent findings on how these barriers are formed, their roles in maintaining water and nutrient balance, and their ecological importance.
  • - It also emphasizes the adaptability of these barriers under environmental stresses (e.g., drought and salinity) and suggests areas needing further research in this field.
View Article and Find Full Text PDF

While drug-drug interactions (DDIs) and their pharmacokinetic (PK) mechanisms are well-studied prior to drug approval, severe adverse drug reactions (SADRs) caused by DDIs often remain underrecognized due to limitations in pre-marketing clinical trials. To address this gap, our study utilized a literature database, applied natural language processing (NLP) techniques, and conducted multi-source electronic health record (EHR) validation to uncover underrecognized DDI-SADR signals that warrant further investigation. PubMed abstracts related to DDIs from January 1962 to December 2023 were retrieved.

View Article and Find Full Text PDF

FeO is a recognized addictive to enhance low solid anaerobic digestion (AD), while for high solid AD challenged by acidity inhibition, its feasibility and mechanism remain unclear. In this study, the positive effect of FeO on high-solids AD of food waste by regulating microbial physiology and energy conservation to enhance mutualistic propionate methanation was documented. The methane yield was increased by 36.

View Article and Find Full Text PDF

The discharge of wastewater containing Congo red (CR) poses a significant threat to aquatic ecosystems and human health, underscoring the urgent need for effective removal methods. In this study, we have developed a novel strategy for efficient removing CR, utilizing the synthesized magnetic hollow Zn/Co zeolitic imidazolate framework composite (MH-ZIF). Comprehensive characterization of MH-ZIF and comparison with contrasting materials were conducted.

View Article and Find Full Text PDF

Ginsenosides, active compounds derived from Panax ginseng, exhibit promising potential in enhancing physical performance. This study investigates the impact of UG0712 (UG), a novel ginsenoside compound, on endurance capacity, body weight, organ weights, blood parameters, and specific transcriptomic changes in liver and muscle tissues using a C57BL/6N mouse model. The mice received UGs orally at three doses: UG50 (50 mg/kg), UG100 (100 mg/kg), and UG200 (200 mg/kg) for a specified duration.

View Article and Find Full Text PDF

Recently, lifestyle medicine (LSM) application has shown feasibility for musculoskeletal pain patients with co-existing lifestyle-related chronic diseases. This study describes early results of a LSM program for musculoskeletal patients with goals to optimize health prior to orthopedic surgery. Fifty-four patients (age: 61 ± 11 years; 39 [72%] females) completed the program from 3/8/22-12/1/23.

View Article and Find Full Text PDF

All-solid-state lithium-sulfur batteries (ASSLSBs) have garnered widespread attention due to their advantages of high energy density and enhanced safety. However, the typical composite structure composed of solid-state electrolyte (SE), discrete conducting carbon black, and microsized sulfur (μ-S) with long-range Li/e conducting path and huge volume changes, suffers from sluggish charge transport and severe electrochemical-mechanical failure. In this work, a unique hierarchical carbon nanocage (hCNC) is applied as a continuous conducting network where nanosized sulfur are confined.

View Article and Find Full Text PDF

Background: Nonsmall cell lung cancer is a leading cause of cancer-related death worldwide. The long noncoding RNA MIR4435-2HG has been shown to play a carcinogenic role in various cancers. The purpose of this study was to explore the role and regulatory mechanism of MIR4435-2HG in non-small cell lung cancer.

View Article and Find Full Text PDF

The escalating energy and environmental crises have spurred significant research interest into developing efficient biological remediation technologies for sustainable contaminant and resource conversion. Integrating engineered nano-micro materials (NMMs) with these biocatalytic processes offers a promising approach to improve the microbial performance for environmental remediation. Core to such material-enhanced hybrid biocatalysis systems (MHBSs) is the rational regulation of metabolic processes with the assistance of NMMs, where a fine engineered mass and electron transfer is beneficial for the improved biocatalytic activity.

View Article and Find Full Text PDF

Aims: The frequency of CTNNB1 mutation, one of the most frequent genetic events in hepatocellular carcinoma (HCC), is lower in Asian countries and in hepatitis B virus (HBV)-related HCCs. In this study, we evaluated the prevalence and types of CTNNB1-mutation in HBV-related HCC and correlated the molecular status with the histomorphological and immunohistochemical features.

Methods And Results: A total of 108 consecutive cases of treatment-naïve, surgically resected HBV-related HCCs were selected.

View Article and Find Full Text PDF

Metabolic dysfunction-associated steatohepatitis (MASH) is a form of chronic liver inflammation associated with metabolic syndrome, such as obesity and a major cause of hepatocellular carcinoma (HCC). Multi-biotics, a soymilk fermented with lactic acid bacteria, are known to alleviate obesity by lowering lipid profile. This study aimed to establish and characterize mouse organoids derived from MASH-related HCC models to evaluate drug responses, particularly focusing on Lenvatinib resistance.

View Article and Find Full Text PDF

Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the distal gastrointestinal tract, including Crohn's disease and ulcerative colitis. This chapter explores the potential of Dendritic cell-associated C-type lectin-1 (Dectin-1), a pattern recognition receptor, as a therapeutic target for IBD. We delve into the multifaceted roles of Dectin-1 in immune response modulation, focusing on its interactions with the gut microbiota and immune system.

View Article and Find Full Text PDF

Current research efforts in polymer and nanotechnology applications are primarily focused on cargo delivery to enhance the therapeutic index, with limited attention being paid to self-molecularly targeted nanoparticles, which may also exhibit significant therapeutic potential. Long-term and anomalous lipid accumulation in the liver is a highly relevant factor contributing to liver diseases. However, the development of the reliable medications and their pharmacological mechanisms remain insufficient.

View Article and Find Full Text PDF
Article Synopsis
  • Cadmium (Cd) is a harmful heavy metal that enters the food chain through plants, posing health risks to humans when consumed.
  • Researchers identified a specific protein called WAKL4 that helps plants tolerate Cd stress by regulating the uptake of this metal.
  • The study reveals that WAKL4 works by interacting with another protein, NRAMP1, to promote its degradation, thus reducing Cd absorption in plants, which could aid in developing crops that accumulate less Cd.
View Article and Find Full Text PDF

Japanese encephalitis virus (JEV) is a significant circulating arbovirus flavivirus and the primary cause of viral encephalitis in Asia. Previous studies have demonstrated that nitazoxanide (NTZ), an antiparasitic gastroenteritis medication classified as a thiazolide, exhibits efficacy against JEV both in vitro and in vivo. To explore the potential antiviral mechanisms, we employed Tandem Mass Tag (TMT)-based quantitative proteomics to identify differentially expressed proteins (DEPs) among three groups: Blank cell group, JEV-infected cell group, and JEV-infected cells treated with NTZ.

View Article and Find Full Text PDF

Tire and road wear microplastics (TRWMPs), as an important type of microplastics, have attracted increasing attention. However, current studies on their contamination within expressway tunnels remain limited. Therefore, we investigated the occurrence characteristics of TRWMPs in dusts from various tunnels, and combined contamination with heavy metals (HMs).

View Article and Find Full Text PDF

Microbiota living in the rhizosphere influences plant growth and fitness, from the opposite perspective; whether host genotypes control its root microbiota is of great interest to forest breeders and microbiologists. To improve low-yield plantations and promote sustainable management of high-throughput sequencing was used to study the chemical properties and microbiome in rhizosphere soil of forests under three genotypes (common , local and ) and three growth stages (sapling stage at 4-year-old, primary fruit stage at 7-year-old, and full fruiting stage at 11-year-old). The results showed that the rhizosphere soil organic matter (OM), nutrient concentrations, diversity, and community composition of the microbiome were significantly varied among different genotypes.

View Article and Find Full Text PDF

Pine wilt disease (PWD), which poses a significant risk to pine plantations across the globe, is caused by the pathogenic agent , also referred to as the pine wood nematode (PWN). A droplet digital PCR (ddPCR) assay was developed for the quick identification of the PWN in order to improve detection sensitivity. The research findings indicate that the ddPCR assay demonstrated significantly higher analysis sensitivity and detection sensitivity in comparison to traditional quantitative PCR (qPCR).

View Article and Find Full Text PDF

We investigate the quantum dynamics of a spin coupling to a bath of independent spins via the dissipaton equation of motion (DEOM) approach. The bath, characterized by a continuous spectral density function, is composed of spins that are independent level systems described by the su(2) Lie algebra, representing an environment with a large magnitude of anharmonicity. Based on the previous work by Suarez and Silbey [J.

View Article and Find Full Text PDF
Article Synopsis
  • Chronic nonspecific low back pain (CNLBP) is a significant public health issue, and while acupuncture is an alternative treatment, its effects on back muscle endurance and duration haven’t been extensively studied.
  • This study involved 30 female patients with CNLBP, randomly assigned to receive either real acupuncture (RA) or sham acupuncture (SA) in two phases, allowing researchers to assess the impact on lower back muscle activity.
  • The findings revealed that RA significantly enhances lumbar extensor endurance and improves blood circulation, leading to reduced levels of blood lactic acid and ammonia after exercise, with the effects lasting about 9 minutes.
View Article and Find Full Text PDF
Article Synopsis
  • Dredging reservoirs helps keep water levels high and makes sure boats can pass through safely.
  • It can also help reduce harmful chemicals and pollutants that can hurt the environment and people.
  • New methods using algae and reeds to manage dredged materials are not only cheaper but also better for the environment, and reusing these materials helps create a greener economy.
View Article and Find Full Text PDF