Multivariate Regression Models for Predicting the Prognosis of Luxation Injuries of Permanent Teeth: Periodontal and Pulp Analyses.

Background: This study aimed to analyse the relationships between injury variables, treatment variables and the status of the periodontium or pulp of luxated teeth.

Materials And Methods: The electronic medical records and imaging data of patients who underwent treatment for luxation injuries of permanent teeth in the paediatric dentistry and dental emergency departments of the Stomatology Hospital, Zhejiang University School of Medicine between 1 January 2012 and 1 January 2022 were retrospectively analysed. First, the patients' records were reviewed to collect background and follow-up imaging data; then, all early clinical variables were reviewed and used to construct models to predict the periodontal and pulp status of the luxated teeth.

Experimental Study on the Backflow Mechanism of Proppants in Induced Fractures and Fiber Sand Control Under the Condition of Large-Scale and Fully Measurable Flow Field.

The proppant backflow in the process of flowback has a great significant effect on gas field development. Therefore, the study of proppant backflow is of great significance for the development and production of gas wells. At present, the physical simulation methods for proppant backflow mainly include the tube perforation model, the slot model, an API standard flow tester, and a large-scale flowback apparatus.

Experimental Study on a Liquid-Solid Phase-Change Autogenous Proppant Fracturing Fluid System.

In this paper, a liquid-solid phase-change autogenous proppant fracturing fluid system (LSPCAP) was proposed to solve the problems that was caused by "sand-carrying" in conventional fracturing technology in oil and gas fields. The characteristic of the new fluid system is that no solid particles will be injected in the whole process of fracturing construction except liquids. The fluid itself will transform into solid particles under the formation temperature to resist the closure stress in the fractures.

Machine learning improves risk stratification of coronary heart disease and stroke.

Background: Coronary heart disease (CHD) and cerebral ischemic stroke (CIS) are two major types of cardiovascular disease (CVD) that are increasingly exerting pressure on the healthcare system worldwide. Machine learning holds great promise for improving the accuracy of disease prediction and risk stratification in CVD. However, there is currently no clinically applicable risk stratification model for the Asian population.

Development and validation of a cardiovascular diseases risk prediction model for Chinese males (CVDMCM).

Background: Death due to cardiovascular diseases (CVD) increased significantly in China. One possible way to reduce CVD is to identify people at risk and provide targeted intervention. We aim to develop and validate a CVD risk prediction model for Chinese males (CVDMCM) to help clinicians identify those males at risk of CVD and provide targeted intervention.

Cholinergic receptor-Wnt pathway controls immune activation by sensing intestinal dysfunction.

Alterations in the intestinal physiology caused by pathogen colonization result in immune activation. To provide insights into the mechanisms underlying the control of immune activation by changes in intestinal homeostasis, we conducted a forward genetic screen for suppressors of immune activation by intestinal distension in Caenorhabditis elegans. Our results indicate that C.

Med-SRNet: GAN-Based Medical Image Super-Resolution via High-Resolution Representation Learning.

High-resolution (HR) medical imaging data provide more anatomical details of human body, which facilitates early-stage disease diagnosis. But it is challenging to get clear HR medical images because of the limiting factors, such as imaging systems, imaging environments, and human factors. This work presents a novel medical image super-resolution (SR) method via high-resolution representation learning based on generative adversarial network (GAN), namely, Med-SRNet.

The complete mitochondrial genome of (Smith, 1874) (Hymenoptera: Formicidae).

(Smith, 1874) belongs to a famously hyperdiverse and ecologically dominant ant genus. The mitochondrial genome of is 15,579 bp in length, and the overall base composition is 78.6% AT.

The transcription factor HLH-26 controls probiotic-mediated protection against intestinal infection through up-regulation of the Wnt/BAR-1 pathway.

Probiotics play a critical role in the control of host intestinal microbial balance, protecting the host from gastrointestinal pathogens, modulating the host immune response, and decreasing host susceptibility to infection. To understand the mechanism underlying the protective effect of probiotics against infections through immune regulation, we examined protection against Salmonella enterica infection following exposure to nonpathogenic Enterococcus faecium in the nematode Caenorhabditis elegans. We found that the transcription factor HLH-26, a REF-1 family member of basic helix-loop-helix transcription factors, was required in the intestine for E.

Myotubularin-related protein protects against neuronal degeneration mediated by oxidative stress or infection.

Microbial infections have been linked to the onset and severity of neurodegenerative diseases such as amyotrophic lateral sclerosis, multiple sclerosis, Alzheimer's disease, but the underlying mechanisms remain largely unknown. Here, we used a genetic screen for genes involved in protection from infection-associated neurodegeneration and identified the gene mtm-10. We then validated the role of the encoded myotubularin-related protein, MTM-10, in protecting the dendrites of Caenorhabditis elegans from degeneration mediated by oxidative stress or Pseudomonas aeruginosa infection.

The transcription regulator BrsR serves as a network hub of natural competence protein-protein interactions in .

Genome evolution is an essential and stringently regulated aspect of biological fitness. For bacteria, natural competence is one of the principal mechanisms of genome evolution and is frequently subject to multiple layers of regulation derived from a plethora of environmental and physiological stimuli. Here, we present a regulatory mechanism that illustrates how such disparate stimuli can be integrated into the natural competence phenotype.

Glycinebetaine: a versatile protectant to improve rice performance against aluminium stress by regulating aluminium uptake and translocation.

Glycinebetaine alleviates the detrimental effects of aluminium stress by regulating aluminium uptake and translocation, maintaining PSII activity, and activating the oxidative defence, thereby maintaining the growth and development of rice. Aluminium (Al) toxicity is one of the primary growth-limiting factors that limits plant growth and crop productivity in acidic soils. Rice (Oryza sativa L.

Baryon Acoustic Oscillations from Integrated Neutral Gas Observations: an instrument to observe the 21cm hydrogen line in the redshift range 0.13 < z < 0.45 - status update.

BINGO (BAO from Integrated Neutral Gas Observations) is a unique radio telescope designed to map the intensity of neutral hydrogen distribution at cosmological distances, making the first detection of Baryon Acoustic Oscillations (BAO) in the frequency band 980 MHz - 1260 MHz, corresponding to a redshift range 0.127 < z < 0.449.

Microbial colonization induces histone acetylation critical for inherited gut-germline-neural signaling.

The gut-neural axis plays a critical role in the control of several physiological processes, including the communication of signals from the microbiome to the nervous system, which affects learning, memory, and behavior. However, the pathways involved in gut-neural signaling of gut-governed behaviors remain unclear. We found that the intestinal distension caused by the bacterium Pseudomonas aeruginosa induces histone H4 Lys8 acetylation (H4K8ac) in the germline of Caenorhabditis elegans, which is required for both a bacterial aversion behavior and its transmission to the next generation.

Longitudinal association between cardiovascular health and arterial stiffness in the Chinese adult population.

Objective: Arterial stiffness may be an intermediary biological pathway involved in the association between cardiovascular health (CVH) and cardiovascular disease. We aimed to evaluate the effect of CVH on progression of brachial-ankle pulse wave velocity (baPWV) over approximately 4 years.

Methods: We included 1315 cardiovascular disease-free adults (49±12 years) who had two checkups from 2010 to 2019.

Relationship between the Plasma Fibulin-1 Levels, Pulse Wave Velocity, and Vascular Age in Asymptomatic Hyperuricemia.

Fibulin-1 (FBLN-1), an elastin-associated extracellular matrix protein, has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease (CVD). We aimed to investigate the relationship between fibulin-1 levels and the risk of CVD by evaluating vascular age derived from the Framingham Heart Study and brachial-ankle Pulse Wave Velocity (baPWV) in patients with asymptomatic hyperuricemia (AHU). In total, 66 patients with AHU and 66 gender- and age-matched healthy individuals were enrolled.

Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression.

Background: Dyslipidemia contributes to the development and progression of arterial stiffness. We aimed to identify the most informative measures of serum lipids and their calculated ratios in terms of arterial stiffness progression risk.

Methods: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and brachial-ankle pulse wave velocity (baPWV) of 659 healthy males (47.

Acetylation of PhoP K88 Is Involved in Regulating Virulence.

The PhoP-PhoQ two-component regulation system of serovar Typhimurium is involved in the response to various environmental stresses and is essential for bacterial virulence. Our previous studies showed that acetylation plays an important role in regulating the activity of PhoP, which consequently mediates the change in virulence of Typhimurium. Here, we demonstrate that a conserved lysine residue, K88, is crucial for the function of PhoP and its acetylation-downregulated PhoP activities.

Premature CD4 T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.

Acquired immune responses mediated by CD4 T cells contribute to the initiation and progression of acute coronary syndrome (ACS). ACS patients show acquired immune system abnormalities that resemble the characteristics of autoimmune dysfunction described in the elderly. This study aimed to investigate the role of premature CD4 T cells senescence in ACS and the underlying mechanism.

Correlation of lower 2 h C-peptide and elevated evening cortisol with high levels of depression in type 2 diabetes mellitus.

Background: A number of studies have explored the association between depression and ghrelin, leptin, and cortisol; further, postprandial C-peptide levels have a therapeutic effect on type 2 diabetes mellitus (T2DM). However, the relationship between C-peptide and depression in patients with diabetes, remains unclear. The aim of this study was to explore the association between depression and ghrelin, leptin, cortisol, and C-peptide in patients with diabetes.

Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects.

BACKGROUND Vascular aging is characterized by increasing arterial stiffness as measured by pulse wave velocity. The present study evaluated the factors influencing vascular aging in Chinese healthy older subjects. MATERIAL AND METHODS Disease- and treatment-free aged (≥60 years) participants were recruited from 2014 to 2019.

Chryseobacterium salivictor sp. nov., a plant-growth-promoting bacterium isolated from freshwater.

A Gram-stain-negative, non-motile, rod-shaped bacterial strain, designated NBC 122, was isolated from freshwater of the Nakdong River Republic of Korea. Growth occurred at pH 5.0-8.

Environmental stress perception activates structural remodeling of extant Streptococcus mutans biofilms.

Transcription regulators from the LexA-like Protein Superfamily control a highly diverse assortment of genetic pathways in response to environmental stress. All characterized members of this family modulate their functionality and stability via a strict coordination with the coprotease function of RecA. Using the LexA-like protein IrvR from Streptococcus mutans, we demonstrate an exception to the RecA paradigm and illustrate how this evolutionary innovation has been coopted to diversify the stress responsiveness of S.

Loss-of-Function Mutation of Soybean R2R3 MYB Transcription Factor Dilutes Tawny Pubescence Color.

Pubescence color of soybean is controlled by two genes, and . In the presence of a dominant allele, dominant and recessive alleles of the locus generate tawny and light tawny (or near-gray) pubescence, respectively. Flavones, responsible for pubescence color, are synthesized two copies of flavone synthase II genes ( and ).

Complete Genome Sequence of sp. Strain NBC 122, a Plant Growth-Promoting Bacterium Isolated from Freshwater.

sp. strain NBC 122, isolated from freshwater of the Nakdong River in the Republic of Korea, was previously characterized as a plant growth-promoting bacterium. Here, we report the genome sequence of sp.