Ruxolitinib versus dexamethasone in hospitalized adults with COVID-19: multicenter matched cohort study.

Background: Several anti-cytokine therapies were tested in the randomized trials in hospitalized patients with severe acute respiratory syndrome coronavirus 2 infection (COVID-19). Previously, dexamethasone demonstrated a reduction of case-fatality rate in hospitalized patients with respiratory failure. In this matched control study we compared dexamethasone to a Janus kinase inhibitor, ruxolitinib.

[Homoarginine level and methionine-homocysteine balance in patients with ischemic heart disease.].

The level of homoarginine (hArg) in terms of prognostic significance may exceed the natriuretic peptides and other well-known markers according to the latest data about the progression of cardiovascular diseases. The lack of data on the association of hArg levels with levels of other metabolites makes it difficult to understand its role in the pathogenesis of cardiovascular diseases. Relationships of hArg and other amino acids, including methionine (Met) and total homocysteine (tHcy), and their ratio in patients with ischemic heart disease were evaluated.

[The level of circulating humanin in patients with ischemic heart disease.].

At present, great interest is caused with evaluation of new markers in blood circulation for the estimation a tissue oxidative metabolism disturbance due to the presence of secondary mitochondrial dysfunction in patients with coronary heart disease. Сoronary heart disease is generally accompanied with a decline in mitochondrial respiration and represents the root cause of metabolic abnormalities in tissues. To gain insight into rate of decline of mitochondrial oxidative metabolism in tissues there were proposed humanin as a new marker.

[OLD AND NEW PROBLEMS IN THE TRAINING OF ANAESTHESIOLOGISTS].

In connection with the upcoming changes in the professional education in Russia, there is a need to adapt the existing system of training of anesthesiologists. We sent questionnaires to 831 anesthesiologists to identify their opinion about the planned transition to continuous medical education. We found that the majority of respondents do not object to the implementation in practice of this system, especially if the educational model will be adapted to the specific requests of practitioners.

[PAIN AFTER CHILDBIRTH AND ITS IMPACT ON QUALITY OF LIFE].

Background: Public attitude towards labor pain and pain relief in labor is not fully formed.

Purpose: To study the frequency of formation of acute and chronic pain during delivery.

Materials And Methods: Retrospectively we surveyed 300 women 18-48 years old, who had childbirth naturally or by caesarean section for 4-6 months before the survey and analyzed the history of their childbirth.