Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats.

Objective: This study was conducted to investigate the regulation of endoplasmic reticulum stress on Nrf2 signaling pathway in the kidneys of rats.

Methods: Rats were divided into twelve groups of six animals each. Some groups were pre-administered with bacitracin or tauroursodeoxycholic acid (TUDCA), and all of them were treated with 5-20 μmol/kg cadmium (Cd) for 48 h.

Analysis of microRNA and gene expression profiling in triazole fungicide-treated HepG2 cell line.

MicroRNA (miRNA) plays an important role in various diseases and in cellular and molecular responses to toxicants. In the present study, we investigated differential expression of miRNAs in response to three triazole fungicides (myclobutanil, propiconazole, and triadimefon). The human hepatoma cell line (HepG2) was treated with the above triazoles for 3 h or 48 h.

Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet.

Background: Ginseng saponin and ginsenosides exert anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems. However, the complicated relationship between the anti-obesity effects of ginseng and gene expression has yet to be defined under in vivo conditions. Therefore, we evaluated the relationship between the anti-obesity effects of Korean red ginseng extract (KRGE) and hepatic gene expression profiles in mice fed long-term on a high-fat diet (HFD) in this study.

[Effects of fluoride on Fas signal pathway in rat incisor cells].

Objective: To investigate the effects of fluoride on Fas expression, caspase-3 and caspase-8 activity and apoptosis in rat incisor cells.

Methods: Forty male SD rats were divided into 4 groups randomly and provided with distilled water containing NaF at the doses of 0, 10, 50 and 100 mg/L respectively. Each group had 10 animals.

Telomerase activity and telomerase reverse transcriptase expression induced by selenium in rat hepatocytes.

Objective: To investigate the effects of sodium selenite on telomerase activity, apoptosis and expression of TERT, c-myc and p53 in rat hepatocytes.

Methods: Selenium at doses of 2.5, 5.

[Effect of selenium and arsenic on oxidative stress, DNA oxidative damage and repair in HepG2 cells].

Objective: To study alone and combined effect of selenium and arsenic on oxidative stress, DNA oxidative damage and repair.

Methods: HepG2 cells were treated with selenium (2.5, 5.

Inhibitory effects of selenium on telomerase activity and hTERT expression in cadmium-transformed 16HBE cells.

Objective: To investigate the effects of sodium selenite on telomerase activity and expression of hTERT mRNA in cadmium-transformed 16HBE cells.

Methods: Telomerase activity and expression of genes were measured after cultured cadmium-transformed 16HBE cells were exposed to sodium selenite at different doses (0.625, 1.

Effects of cadmium on hepatocellular DNA damage, proto-oncogene expression and apoptosis in rats.

Objective: To study the effects of cadmium on hepatocellular DNA damage, expression of proto-oncogenes c-myc, c-fos, and c-jun as well as apoptosis in rats.

Methods: Cadmium chloride at the doses of 5, 10, and 20 micromol/kg was given to rats by i.p.

Effects of selenium and zinc on renal oxidative stress and apoptosis induced by fluoride in rats.

Objective: To study the effects of selenium and zinc on oxidative stress, apoptosis, and cell cycle changes in rat renal cells induced by fluoride.

Methods: Wistar rats were given distilled water containing sodium fluoride (50 mg/L NaF) and were gavaged with different doses of selenium-zinc preparation for six months. Four groups were used and each group had eight animals (four males and four females).

DNA damage, apoptosis and C-myc, C-fos, and C-jun overexpression induced by selenium in rat hepatocytes.

Objective: To study the effects of selenium on DNA damage, apoptosis and c-myc, c-fos, and c-jun expression in rat hepatocytes.

Methods: Sodium selenite at the doses of 5, 10, and 20 micromol/kg was given to rats by i.p.

[Effects of selenium on expression of TERT, c-Myc and p53 induced by cadmium in rat liver].

Objective: To study the effects of sodium selenite on expression of telomerase reverse transcriptase mRNA, c-Myc and p53 induced by cadmium chloride in rat liver.

Methods: Male SD rats were divided randomly into 6 groups, each group had 5 animals. The groups comprised the control group, Se group (5 micromol/kg sodium selenite), 5 micromol/kg cadmium chloride group, 10 micromol/kg cadmium chloride group, Se (5 micromol/kg sodium selenite) + 5 micromol/kg cadmium chloride group, Se (5 micromol/kg sodium selenite) + 10 micromol/kg cadmium chloride group.

[Effects of selenium on benzo[a] pyrene-induce DNA damage in mouse lung cells].

Objective: To explore the effects of selenium on DNA damage induced by benzo[a] pyrene (BaP) in mouse lung cells.

Methods: Sodium selenite was given to Kunming male mice by i.p.

[Effects of selenium on rat hepatocellular DNA damage, apoptosis and changes of cell cycle induced by cadmium in vivo].

Objective: This study was conducted to study the effects of sodium selenite on rat hepatocellular DNA damage, apoptosis, changes of cell cycle and DNA relative content induced by cadmium chloride in vivo.

Methods: Both sodium selenite at the dose of 5 micromol/kg and cadmium chloride at the dose of 5 micromol/kg, 10 micromol/kg and 20 micromol/kg were given to rats by i.p.

[Effects of selenium on rat hepatocellular DNA damage induced by cadmium in vitro].

Objectives: This study was conducted to explore effects of selenium on rat hepatocellular DNA damage induced by cadmium in vitro.

Method: Sodium selenite was added at concentrations of 8.75, 17.