Comprehensive analyses of meat quality and metabolome alterations with aging under different aging methods in beef.

The impacts of various aging techniques on meat quality and metabolism alterations over time were investigated. Meat tenderness improved with aging, whereas prolonged aging negatively impacted color and oxidative stability. Dry-aging (DA) group exhibited significantly higher (P < 0.

Liquid crystal-based image holography with broadband response and polarization insensitivity.

We propose and experimentally demonstrate liquid crystal-based computer-generated image holography enabled by the Pancharatnam-Berry phase modulation. Such a device exhibits distinctive properties, such as natural light illumination, polarization insensitivity, broadband optical response, high polarization conversion efficiency, and direct visibility to the naked eye. These unique attributes make this type of image holography a promising avenue for applications in optical information storage, anti-counterfeiting, and advanced information displays.

Flexible Phase Change Materials with High Energy Storage Density Based on Porous Carbon Fibers.

Phase change fibers (PCFs) can effectively store and release heat, improve energy efficiency, and provide a basis for a wide range of energy applications. Improving energy storage density and preserving flexibility are the primary issues in the efficient manufacture and application development of PCFs. Herein, we have successfully fabricated a suite of flexible PCFs with high energy storage density, which use hollow carbon fibers (HCFs) encapsulated phase change materials (PCMs) to provide efficient heat storage and release, thereby enhancing energy efficiency and underpinning a broad range of energy applications.

GmERF13 mediates salt inhibition of nodulation through interacting with GmLBD16a in soybean.

While the genetic regulation of nodule formation has been well explored, the molecular mechanisms by which abiotic stresses, such as salt stress, impede nodule formation remain largely elusive. Here, we identify four APETALA2/Ethylene Responsive Factor (AP2/ERF) transcription factors, GmERF13s, that are induced by salt stress and play key roles in salt-repressed nodulation. Loss of GmERF13 function increases nodule density, while its overexpression suppresses nodulation.

Fusobacterium nucleatum promotes colorectal cancer liver metastasis via miR-5692a/IL-8 axis by inducing epithelial-mesenchymal transition.

Background: The association between the intestinal microbiota and colorectal cancer (CRC) has been extensively studied, with Fusobacterium nucleatum (F. nucleatum, FN) being found in high abundance in colorectal cancer tissues. Previous research has emphasized the significant role of F.

Punicalagin inhibits excessive autophagy and improves cerebral function in neonatal rats with hypoxia-ischemia brain injury by regulating AKT-FOXO4.

Background: Neonatal hypoxic-ischemic encephalopathy (HIE) has a high incidence and mortality rate, representing a significant patient burden. Therefore, treatment strategies that work synergistically with hypothermic therapies are urgently required. Punicalagin (PUN) is a natural and safe polyphenol with anti-inflammatory functions whose excellent water solubility and safety make it an advantageous perinatal medication.

Prioritization of climate change mitigation strategies for coastal regions using the Analytic Hierarchy Process.

This study utilizes the Analytic Hierarchy Process (AHP) to prioritize climate change mitigation strategies for coastal regions systematically. The AHP, a robust data-driven decision-making framework, was employed to evaluate five strategies: Mangrove Restoration, Zoning and Building Codes, Seawalls, Coral Reef Protection, and Relocation Programs. The analysis revealed that Mangrove Restoration emerged as the most effective strategy, achieving the highest score of 0.

Hypoalbuminemia and cisplatin-induced acute kidney injury.

Background: Cisplatin binds to serum albumin in the body at a rate of 90%, and high levels of free cisplatin are a significant cause of its nephrotoxicity. Therefore, hypoalbuminemia theoretically poses a significant risk factor for cisplatin-induced acute kidney injury (CIA) and can be easily corrected. However, existing research results are inconsistent.

Chromosome-scale genome assembly and gene annotation of the Alligator Gar (Atractosteus spatula).

Given the aggressive nature and robust survival capabilities of the alligator gar (Atractosteus spatula), if it was to exist in a new environment as an invasive species, it could cause significant disruption to the invaded ecosystem. Building on the continuity and completeness of the existing draft genome were not optimal, this study has updated a high-quality genome of the alligator gar at the chromosome level, which was assembled using Oxford Nanopore Technology and chromatin interaction mapping (Hi-C) sequencing techniques. In summary, the alligator gar genome in this study was 1.

Effect of Community-Based Integrated Care for Patients With Diabetes and Depression (CIC-PDD) in China: A Pragmatic Cluster-Randomized Trial.

Objective: To develop a care model for patients with both diabetes and depression and assess the model's effectiveness.

Research Design And Methods: In this pragmatic cluster randomized trial, we allocated eight community health centers into two groups: the enhanced usual care group and the intervention group. A comprehensive care plan was developed for the intervention group based on the integrated care model.

EGFR and MUC1 as dual-TAA drug targets for lung cancer and colorectal cancer.

Background: Epidermal growth factor receptor (EGFR) is a key protein in cellular signaling that is overexpressed in many human cancers, making it a compelling therapeutic target. On-target severe skin toxicity has limited its clinical application. Dual-targeting therapy represents a novel approach to overcome the challenges of EGFR-targeted therapies.

Construction of bFGF/heparin and FeO nanoparticles functionalized scaffolds aiming at vascular repair and magnetic resonance imaging monitoring.

This work develops a bioactive basic fibroblast growth factor (bFGF)/heparin and FeO nanoparticles (NPs) trifunctionalized degradable construct with the potential of using as a vascular tissue engineering scaffold with the aim of improving vascular repair and regeneration therapy. The covalent modification of heparin onto the poly(lactic acid) (PLA)-gelatin (Gel)-FeO (PGF) scaffold improves the hydrophilicity of the scaffold. Furthermore, the electrostatic adsorption of bFGF on heparin allows for a more consistent and prolonged release of bFGF in situ, hence increasing the stability and effectiveness of bFGF around the surrounding vascular tissues.

Bioactive Peptide Hydrogel Scaffold with High Fluidity, Thermosensitivity, and Neurotropism in 3D Spatial Structure for Promoted Repair of Spinal Cord Injury.

Spinal cord injury (SCI) has been considered a clinically challenging disease that is characterized by local disturbance of the microenvironment, which inhibits post-injury neural regeneration. The simulation of a microenvironment conducive to the regeneration of spinal cord is beneficial for SCI repair. In this study, bioactive composite hydrogels are developed that mimic the regenerative microenvironment of spinal cord for enhanced SCI repair.

Locking-Fluorescence Signals Regulated CRISPR/Cas12a Biosensor Based on Metal-Organic Framework for Sensitive Detection of .

The efficient, sensitive, and rapid detection of () in food and food products is important to ensure food safety and health. This study developed a fluorescence biosensing assay that integrated recombinase-aided amplification (RAA) and CRISPR/Cas12a with a zeolitic imidazolate framework-8@fluorescein sodium (ZIF-8@FLS) nanocomposite for the sensitive detection of . In this approach, using RAA as a preamplification module, CRISPR/Cas12a-AChE as a target recognition and dual-enzyme cascade amplification module, and the prepared ZIF-8@FLS with high porosity and rapid pH responsiveness as a fluorescence signal explosive amplification module, the RAA-CRISPR/Cas12a-ZIF-8@FLS biosensor was constructed.

Acupuncture and Moxibustion in the Treatment of Gynecological Perioperative Anxiety: A Systematic Review and Meta-Analysis.

Objective: This systematic review and meta-analysis aims to investigate the effectiveness and safety of acupuncture and moxibustion in managing perioperative anxiety during gynecological surgery.

Methods: Relevant studies published from the establishment of the databases to March 20, 2023, were searched in PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, and CBM. Literature screening and data extraction were independently conducted by two investigators.

The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.

Background: Neuroinflammation and oxidative stress, mediated by microglial activation, hinder the development of oligodendrocytes (OLs) and delay myelination in preterm infants, leading to white matter injury (WMI) and long-term neurodevelopmental sequelae. Peroxisome proliferator-activated receptor gamma (PPAR-γ) has been reported to inhibit inflammation and oxidative stress via modulating microglial polarization in various central nervous system diseases. However, the relationship between PPAR-γ and microglial polarization in neonatal WMI is not well understood.

An inverted U-shaped relationship between work-family conflict and job burnout among village clinic doctors: the moderating effect of information and communication technology use.

Background: Village clinic doctors are an integral part of the rural healthcare workforce. With the advancement of science and technology and the coronavirus disease 2019 (COVID-19) pandemic, the prevalence of remote work and the use of information and communication technologies (ICT) have increased significantly. However, these developments have also had an impact on the work family balance and mental well-being of village clinic doctors.

FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.

White matter injury (WMI), the most common type of brain damage in infants born preterm, is characterized by failure in oligodendrocyte progenitor cell maturation and myelination, thereby contributing to long-term neurological impairments. Regrettably, effective therapies for promoting remyelination and improving function are currently lacking for this growing population affected by WMI. Recombinant human fibroblast growth factor (rhFGF) 21 modulated microglial activation and then ameliorated brain damage and improved neurological deficits in several central nervous system diseases.

Attention allocation in foreign language reading anxiety during lexical processing - An ERP study with cue-target paradigm.

Extensive behavioral and pedagogical studies emphasize the negative impact of foreign language reading anxiety on foreign language reading. This study investigated whether foreign language reading anxiety is correlated with dysregulation of attentional allocation while foreign language reading. We used event-related potential (ERP) indices as biomarkers to examine attention allocation between groups with high foreign language reading anxiety (HFLRA) and low foreign language reading anxiety (LFLRA) using a cue-target paradigm under conditions that posed high (valid condition) or low (invalid condition) expectations on target location.

Microfluidics-Assisted Polymer Vesicle Budding in Emulsion Systems: A Promising Approach for the Preparation and Application of Polymer Vesicles.

The challenge of producing polymer vesicles remains difficult, despite numerous attempts to modulate the kinetics of polymer vesicle budding and achieve precise control over the membrane characteristics. An innovative approach that incorporates the use of copolymer-loaded single-emulsion droplets is proposed to address this challenge. This method enables the precise manipulation of micelles and polymer vesicles' composition, structures and dimensions.

Biological Mechanisms of Aflatoxin B-Induced Bile Metabolism Abnormalities in Ducklings.

This study investigated the effects and biological mechanisms of aflatoxin B (AFB) on the health and bile metabolism of ducklings. Forty-eight 1-day-old ducklings were randomly assigned to two groups, with six replicates per group. The control group was fed a basic diet, while the AFB group received a diet containing 90 µg/kg of AFB.

Meat exudate metabolomics reveals the impact of freeze-thaw cycles on meat quality in pork loins.

The aim of this study was to explore the effects of freeze-thaw (FT) cycles on meat quality, myofibrillar protein gelation and emulsification properties, and exudate metabolome changes in pork loins. Meat tenderness improved ( < 0.05), whereas water-holding capacity (WHC), meat color attributes declined ( < 0.